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Lack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjogren's syndrome

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dc.creatorTobon, GJspa
dc.creatorCorrea, PAspa
dc.creatorGomez, LMspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-06-11T13:21:23Z
dc.date.available2020-06-11T13:21:23Z
dc.date.created2005spa
dc.description.abstractTo investigate the previously reported association of tumor necrosis factor alpha (TNF) -308 single nucleotide polymorphism (SNP) with the clinical coarse and immunological features in patients with systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS).Methods The studied group consisted of 113 consecutive SLE and 65 pSS patients. TNF -308 SNP was determined by the polymerase chain reactioin-restriction fragment length polymorphism technique. Clinical and immunological characteristics were assessed according to a standard protocol that included disease activity (SLEDAI) and damage (SLICC Damage Index). Serum TNF alpha levels were measared in samples collected from 32 patients with SLE and 16 with pSS by enzyme-linked immunosorbent assay.Results The TNF2 allele (A) was observed in 46% and 54% of SLE and pSS patients, respectively. We failed to find any significant association between the -308 SNP and disease manifestations, the presence of antoantibodies or cytokine levels in either group.Conclusion TNF -308 SNP (TNF2) does not exhibit a significant influence on the disease course or immunological response in SLE and pSS. Other genetic and/or environmental factors seem to be required and to be more important than TNF2 allele for the progression of these diseases.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0392-856X
dc.identifier.issn1593-098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24854
dc.language.isoeng
dc.publisherPacini Editore SpAspa
dc.relation.citationEndPage344
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage339
dc.relation.citationTitleCLINICAL AND EXPERIMENTAL RHEUMATOLOGY
dc.relation.citationVolumeVol. 23
dc.relation.ispartofCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, ISSN:0392-856X ; 1593-098X, Vol.23, No.3 (2005); pp. 339-344spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectfactor de necrosis tumoralspa
dc.subjectpolimorfismospa
dc.subjectsíndrome de Sjogren primariospa
dc.subjectlupus eritematoso sistémicospa
dc.subjectFactor de necrosis tumoralspa
dc.subjectPromotor Tnf-alfaspa
dc.subjectEsclerosis múltiplespa
dc.subjectPolimorfismos de genesspa
dc.subjectCitocinas Th1 / th2spa
dc.subjectGlándulas salivalesspa
dc.subjectSusceptibilidadspa
dc.subjectExpresiónspa
dc.subjectEnfermedadspa
dc.subjectSlespa
dc.subject.keywordtumor necrosis factorspa
dc.subject.keywordpolymorphismspa
dc.subject.keywordprimary Sjogren's syndromespa
dc.subject.keywordsystemic lupus erythematosusspa
dc.subject.keywordTumor-necrosis-factorspa
dc.subject.keywordTnf-alpha promoterspa
dc.subject.keywordMultiple-sclerosisspa
dc.subject.keywordGene polymorphismsspa
dc.subject.keywordTh1/th2 cytokinesspa
dc.subject.keywordSalivary-glandsspa
dc.subject.keywordSusceptibilityspa
dc.subject.keywordExpressionspa
dc.subject.keywordDiseasespa
dc.subject.keywordSlespa
dc.titleLack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjogren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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