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A systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic cardiomyopathy

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dc.creatorJiménez P.spa
dc.creatorJaimes J.spa
dc.creatorPoveda C.spa
dc.creatorRamírez, Juan Davidspa
dc.date.accessioned2020-05-25T23:57:53Z
dc.date.available2020-05-25T23:57:53Z
dc.date.created2019spa
dc.description.abstractChagas disease is a complex tropical pathology caused by the kinetoplastid Trypanosoma cruzi. This parasite displays massive genetic diversity and has been classified by international consensus in at least six Discrete Typing Units (DTUs) that are broadly distributed in the American continent. The main clinical manifestation of the disease is the chronic chagasic cardiomyopathy (CCC) that is lethal in the infected individuals. However, one intriguing feature is that only 30-40% of the infected individuals will develop CCC. Some authors have suggested that the immune response, host genetic factors, virulence factors and even the massive genetic heterogeneity of T. cruzi are responsible of this clinical pattern. To date, no conclusive data support the reason why a few percentages of the infected individuals will develop CCC. Therefore, we decided to conduct a systematic review analysing the host genetic factors, immune response, cytokine production, virulence factors and the plausible association of the parasite DTUs and CCC. The epidemiological and clinical implications are herein discussed. © Cambridge University Press 2018.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1017/S0031182018001506
dc.identifier.issn14698161
dc.identifier.issn00311820
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22760
dc.language.isoengspa
dc.publisherCambridge University Pressspa
dc.relation.citationEndPage283
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage269
dc.relation.citationTitleParasitology
dc.relation.citationVolumeVol. 146
dc.relation.ispartofParasitology, ISSN:14698161, 00311820, Vol.146, No.3 (2019); pp. 269-283spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053737312&doi=10.1017%2fS0031182018001506&partnerID=40&md5=18581157e8e7d0cfb872b1319a8f6bc5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCytokinespa
dc.subject.keywordinnateeng
dc.subject.keywordHost factorspa
dc.subject.keywordVirulence factorspa
dc.subject.keywordCytokinespa
dc.subject.keywordVirulence factorspa
dc.subject.keywordAdaptive immunityspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordChronic diseasespa
dc.subject.keywordCytokine productionspa
dc.subject.keywordGenetic heterogeneityspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHeredityspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordMetabolomicsspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordCardiomyopathyspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordImmunologyspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordParasitologyspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordCardiomyopathiesspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordCytokinesspa
dc.subject.keywordGenetic heterogeneityspa
dc.subject.keywordHost-parasite interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordVirulence factorsspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordChronic chagasic cardiomyopathyspa
dc.subject.keywordDtusspa
dc.subject.keywordGenetic factorsspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordVirulencespa
dc.titleA systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic cardiomyopathyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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