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Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity

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dc.creatorMolano González, Nicolás
dc.creatorRojas Quintana, Manuel Eduardospa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Nieva, Yovana
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRodríguez Velandia, Yhojan Alexisspa
dc.creatorRodríguez Jiménez, Mónica María del Pilar
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:55Z
dc.date.available2020-05-25T23:55:55Z
dc.date.created2019spa
dc.description.abstractAutoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i.e., polyautoimmunity - PolyA). In the present exploratory study, a mixed-cluster analysis of the most common autoimmune rheumatic diseases (ARDs) was done. A total of 187 consecutive women with established systemic lupus erythematosus (n = 70), rheumatoid arthritis (n = 51), systemic sclerosis (n = 35) and Sjögren's syndrome (n = 31) were included. A comprehensive clinical, autoantibody and cytokine assessment was simultaneously done. Total PolyA was registered in 142 (75.9%) patients. Six clusters were obtained, built mainly on autoantibodies: PolyA-I to -VI. The PolyA-III cluster showed the highest frequency of overt PolyA (p = 0.01), and the PolyA-I, -III, and -IV clusters exhibited the highest positivity for IL-12/23p40 (p = 0.015). These results provide new insights into the pathophysiology of PolyA and warrant prospective validation to enable development of a more accurate taxonomy of ARDs. © 2018 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2018.11.002
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22263
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage32
dc.relation.citationStartPage24
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 98
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.98,(2019); pp. 24-32spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056602650&doi=10.1016%2fj.jaut.2018.11.002&partnerID=40&md5=57791f14737e0d657b9a97fe62973ed0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlpha interferonspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordGamma interferonspa
dc.subject.keywordGranulocyte colony stimulating factorspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordInterleukin 10spa
dc.subject.keywordInterleukin 12spa
dc.subject.keywordInterleukin 13spa
dc.subject.keywordInterleukin 17spa
dc.subject.keywordInterleukin 1betaspa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordInterleukin 4spa
dc.subject.keywordInterleukin 5spa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordInterleukin 8spa
dc.subject.keywordInterleukin 9spa
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordAdultspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMyasthenia gravisspa
dc.subject.keywordOnset agespa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProspective studyspa
dc.subject.keywordRheumatic diseasespa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordInterleukin-12/23p40spa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordTaxonomyspa
dc.titleCluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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