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Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS

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dc.creatorCaicedo Dorado, Alexander
dc.creatorAlderliesten, Thomasspa
dc.creatorNaulaers, Gunnarspa
dc.creatorLemmers, Petraspa
dc.creatorVan Bel, Frankspa
dc.creatorVan Huffel, Sabinespa
dc.date.accessioned2020-08-28T15:49:58Z
dc.date.available2020-08-28T15:49:58Z
dc.date.created2014-03-22spa
dc.description.abstractLabetalol is a drug used in the treatment of hypertensive disorders of pregnancy (HDP). In a previous study we investigated the influence of the maternal use of labetalol on the cerebral autoregulation (CA) mechanism of neonates. In that study, we found that labetalol induces impaired CA during the first day of life, with CA returning to a normal status by the third day after birth. This effect was hypothesized to be caused by labetalol-induced vasodilation. However, no strong evidence for this claim was found. In this study we aim to find stronger evidence for the vasodilation effect caused by labetalol, by investigating its effect on the neurogenic mechanism (NM) involved in CA. The status of the NM was assessed by means of transfer function analysis between the low frequency content of the autonomic control activity (LFA), obtained by processing of the heart rate (HR), and the regional cerebral oxygen saturation (rScO2). We found that neonates from mothers treated with labetalol presented a lower LFA and an impaired NM response during the first day of life, with values returning to normal by the end of the third day. These results reflect a vasodilation effect caused by labetalol, and indicate that the impaired CA observed in the previous study is caused by vasodilation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-1-4939-0620-8_23
dc.identifier.issnISBN: 978-1-4939-0583-6
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28874
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage179
dc.relation.citationStartPage173
dc.relation.citationTitleAdvances in Experimental Medicine and Biology
dc.relation.citationVolumeVol. 812
dc.relation.ispartofAdvances in Experimental Medicine and Biology, ISBN: 978-1-4939-0583-6, Vol.812 (2014); pp. 173-179spa
dc.relation.urihttps://link.springer.com/chapter/10.1007/978-1-4939-0620-8_23spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceAdvances in Experimental Medicine and Biologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordLabetalolspa
dc.subject.keywordHypertensive disorders of pregnancyspa
dc.subject.keywordVasodilation effectspa
dc.subject.keywordNeurogenic mechanismspa
dc.subject.keywordCerebral autoregulationspa
dc.titleInfluence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRSspa
dc.title.TranslatedTitleInfluencia del uso materno de labetalol en el mecanismo neurogénico de autorregulación cerebral evaluado mediante NIRSspa
dc.typebookParteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaParte de librospa
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