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The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon

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dc.creatorCowley, Thelma R.spa
dc.creatorGonzález Reyes, Rodrigo Esteban
dc.creatorRichardson, Jill C.spa
dc.creatorVirley, Davidspa
dc.creatorUpton, Neilspa
dc.creatorLynch, Marina A.spa
dc.date.accessioned2020-08-06T16:20:46Z
dc.date.available2020-08-06T16:20:46Z
dc.date.created2013spa
dc.description.abstractA non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer’s disease and Huntington’s disease. Dimebon exerts several effects in addition to its anti-histaminergic effect, and of particular interest is its ability to enhance cognitive function in several models. The mechanism underlying this is unknown though it has been suggested that it may be associated with its anti-cholinergic action. Dimebon has also been reported to be neuroprotective, perhaps as a result of its ability to stabilize mitochondria. We considered that these effects might impact on the well-described age-related impairment in spatial learning and therefore examined the effect of repeated administration of dimebon on performance of young and aged animals in the Morris water maze. Whereas a clear age-related deficit was observed, dimebon failed to exert any effect on performance. Similarly, dimebon exerted no effect on the age-related increase in hippocampal expression of several markers of microglial and astroglial activation. We conclude that, despite its cognitive enhancing effects in some models, dimebon failed to modulate the deficit in spatial learning in aged rats and the evidence suggests that the drug does not possess anti-inflammatory properties.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s11064-012-0884-0
dc.identifier.issnISSN: 0364-3190
dc.identifier.issnEISSN: 1573-6903
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26136
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage1195
dc.relation.citationIssueNo. 38
dc.relation.citationStartPage1190
dc.relation.citationTitleNeurochemical Research
dc.relation.ispartofNeurochemical Research, ISSN: 0364-3190;EISSN: 1573-6903, No.38 (2013);pp.1190-1195spa
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs11064-012-0884-0spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceNeurochemical Researchspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAgespa
dc.subject.keywordDimebonspa
dc.subject.keywordMicrogliaspa
dc.subject.keywordAstrocytesspa
dc.subject.keywordSpatial learningspa
dc.subject.keywordHippocampusspa
dc.titleThe age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebonspa
dc.title.TranslatedTitleEl dimebon no afecta la gliosis relacionada con la edad y el déficit acompañante en el aprendizaje espacial.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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