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Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorCorrea, PAspa
dc.creatorMantilla, RDspa
dc.creatorArcos-Burgos, Mspa
dc.date.accessioned2020-08-19T14:40:29Z
dc.date.available2020-08-19T14:40:29Z
dc.date.created2002-02-21spa
dc.description.abstractIn most ethnic groups genetic susceptibility to rheumatoid arthritis (RA) is associated with certain HLA-DRB1 alleles encoding a similar sequence motif called the 'shared epitope' (SE) spanning amino acid positions 70 to 74 in the third diversity region of the outermost domain of the HLA-DRB1 molecule. We examined the association of the SE and RA in 83 Colombian women with established RA and 90 healthy controls. The group HLA-DRB1*04 was associated with RA with respect to controls (47% vs 18%, respectively. OR: 4.1, 95%CI: 2.1-8.2, P < 0.001). HLA-DRB1 alleles carrying the SE QRRAA, but not those carrying QKRAA or RRRAA, were associated with disease (OR: 3.7, 95%CI: 1.73-7.83, P = 0.0009). This association was stronger among HLA-DRB1*04 carriers (OR: 23, 95%CI: 1.3-414, P = 0.002). In our population, the SE QRRAA expressed in DRB1*04 alleles appears critical in identifying women with increased susceptibility to RA.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/sj.gene.6363833
dc.identifier.issnISSN: 1466-4879
dc.identifier.issnEISSN: 1476-5470
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26904
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationEndPage58
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage56
dc.relation.citationTitleGenes and Immunity
dc.relation.citationVolumeVol. 3.
dc.relation.ispartofGenes and Immunity, ISSN: 1466-4879;EISSN: 1476-5470, Vol.3. No.1 (2002); pp. 56–58spa
dc.relation.urihttps://www.nature.com/articles/6363833.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceGenes and Immunityspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordHLA-DRB1spa
dc.subject.keywordShared epitopespa
dc.subject.keywordNon-Caucasiansspa
dc.subject.keywordColombiaspa
dc.titleRheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA allelesspa
dc.title.TranslatedTitleLa asociación de artritis reumatoide en la población colombiana está restringida a los alelos HLA-DRB1 * 04 QRRAAspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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