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Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression

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dc.creatorSwanson, James M.spa
dc.creatorArnold, L. Eugenespa
dc.creatorMolina, Brooke S.G.spa
dc.creatorSibley, Margaret H.spa
dc.creatorHechtman, Lily T.spa
dc.creatorHinshaw, Stephen P.spa
dc.creatorAbikoff, Howard B.spa
dc.creatorStehli, Annamariespa
dc.creatorOwens, Elizabeth B.spa
dc.creatorMitchell, John T.spa
dc.creatorNichols, Quyenspa
dc.creatorHoward, Andreaspa
dc.creatorGreenhill, Laurence L.spa
dc.creatorHoza, Betsyspa
dc.creatorNewcorn, Jeffrey H.spa
dc.creatorJensen, Peter S.spa
dc.creatorVitiello, Benedettospa
dc.creatorWigal, Timothyspa
dc.creatorEpstein, Jeffery N.spa
dc.creatorTamm, Leannespa
dc.creatorLakes, Kimberly D.spa
dc.creatorWaxmonsky, Jamesspa
dc.creatorLerner, Marcspa
dc.creatorEtcovitch, Joyspa
dc.creatorMurray, Desiree W.spa
dc.creatorMuenke, Maximilianspa
dc.creatorAcosta, Maria T.spa
dc.creatorArcos-Burgos, Mauricio
dc.creatorPelham, William E.spa
dc.creatorKraemer, Helena C.spa
dc.date.accessioned2020-05-25T23:55:59Z
dc.date.available2020-05-25T23:55:59Z
dc.date.created2017spa
dc.description.abstractBackground: The Multimodal Treatment Study (MTA) began as a 14-month randomized clinical trial of behavioral and pharmacological treatments of 579 children (7–10 years of age) diagnosed with attention-deficit/hyperactivity disorder (ADHD)-combined type. It transitioned into an observational long-term follow-up of 515 cases consented for continuation and 289 classmates (258 without ADHD) added as a local normative comparison group (LNCG), with assessments 2–16 years after baseline. Methods: Primary (symptom severity) and secondary (adult height) outcomes in adulthood were specified. Treatment was monitored to age 18, and naturalistic subgroups were formed based on three patterns of long-term use of stimulant medication (Consistent, Inconsistent, and Negligible). For the follow-up, hypothesis-generating analyses were performed on outcomes in early adulthood (at 25 years of age). Planned comparisons were used to estimate ADHD-LNCG differences reflecting persistence of symptoms and naturalistic subgroup differences reflecting benefit (symptom reduction) and cost (height suppression) associated with extended use of medication. Results: For ratings of symptom severity, the ADHD-LNCG comparison was statistically significant for the parent/self-report average (0.51 ± 0.04, p  less than .0001, d = 1.11), documenting symptom persistence, and for the parent/self-report difference (0.21 ± 0.04, p  less than .0001, d =.60), documenting source discrepancy, but the comparisons of naturalistic subgroups reflecting medication effects were not significant. For adult height, the ADHD group was 1.29 ± 0.55 cm shorter than the LNCG (p  less than .01, d =.21), and the comparisons of the naturalistic subgroups were significant: the treated group with the Consistent or Inconsistent pattern was 2.55 ± 0.73 cm shorter than the subgroup with the Negligible pattern (p  less than .0005, d =.42), and within the treated group, the subgroup with the Consistent pattern was 2.36 ± 1.13 cm shorter than the subgroup with the Inconsistent pattern (p  less than .04, d =.38). Conclusions: In the MTA follow-up into adulthood, the ADHD group showed symptom persistence compared to local norms from the LNCG. Within naturalistic subgroups of ADHD cases, extended use of medication was associated with suppression of adult height but not with reduction of symptom severity. © 2017 Association for Child and Adolescent Mental Health.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/jcpp.12684
dc.identifier.issn00219630
dc.identifier.issn14697610
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22286
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage678
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage663
dc.relation.citationTitleJournal of Child Psychology and Psychiatry and Allied Disciplines
dc.relation.citationVolumeVol. 58
dc.relation.ispartofJournal of Child Psychology and Psychiatry and Allied Disciplines, ISSN:00219630, 14697610, Vol.58, No.6 (2017); pp. 663-678spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85015163743&doi=10.1111%2fjcpp.12684&partnerID=40&md5=435a7e392fb0eb9b6a3d920f5071a62fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAftercarespa
dc.subject.keywordAttention deficit disorderspa
dc.subject.keywordBody heightspa
dc.subject.keywordChildspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow upspa
dc.subject.keywordHumanspa
dc.subject.keywordMalespa
dc.subject.keywordMultimodality cancer therapyspa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordRandomized controlled trialspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAftercarespa
dc.subject.keywordAttention deficit disorder with hyperactivityspa
dc.subject.keywordBody heightspa
dc.subject.keywordChildspa
dc.subject.keywordCombined modality therapyspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow-up studiesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordOutcome assessment (health care)spa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAttention-deficit/hyperactivity disorderspa
dc.subject.keywordFollow-up studiesspa
dc.subject.keywordGrowthspa
dc.subject.keywordLongitudinal studiesspa
dc.subject.keywordMedication effectsspa
dc.subject.keywordTreatment trialsspa
dc.titleYoung adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppressionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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