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Genetic epidemiology of rheumatoid arthritis: what to expect from Latin America?

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dc.creatorDelgado-Vega A.M.spa
dc.creatorMartín J.spa
dc.creatorGranados J.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:02:51Z
dc.date.available2020-05-26T00:02:51Z
dc.date.created2006spa
dc.description.abstractRheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammation and destruction of the synovial joints. It affects approximately 0.5% of the Latin-American population and is three times more common in women than in men. Evidence of familial aggregation (lambdas=2-17) was the first indication of a genetic susceptibility to disease. As in other autoimmune diseases, it has a complex genetic basis. Results from whole-genome scans indicate that the HLA region contains a significant and consistent set of linked loci. However, HLA accounts for only one-third of the genetic susceptibility of disease, indicating that non-HLA genes are also involved in the disease susceptibility. In Latin-America, association with HLA-DRB1*0404 and TNF -308A alleles has been uniformly established; however, many other candidate genes remain to be studied. The identification of genetic factors conferring susceptibility to rheumatoid arthritis will contribute to the knowledge of the pathogenic mechanisms, ability to predict its occurrence, the development of diagnostic tools, prognosis, and treatment. The genetic epidemiology of rheumatoid arthritis is herein reviewed; a set of recommendations is provided for the design, analysis and interpretation of genetic association studies in the context of Latin-American populations.eng
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23532
dc.language.isoengspa
dc.relation.citationEndPage584
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage562
dc.relation.citationTitleBiomédica : revista del Instituto Nacional de Salud
dc.relation.citationVolumeVol. 26
dc.relation.ispartofBiomédica : revista del Instituto Nacional de Salud, Vol.26, No.4 (2006); pp. 562-584spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34249331916&partnerID=40&md5=3b68d13e9e13e3c6dfe4a35f68f24372spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordRheumatoideng
dc.subject.keywordHLA-DRB1 antigenspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHumanspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSouth and Central Americaspa
dc.subject.keywordArthritiseng
dc.subject.keywordEpidemiologic Studiesspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordHLA-DR Antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin Americaspa
dc.titleGenetic epidemiology of rheumatoid arthritis: what to expect from Latin America?spa
dc.title.TranslatedTitleEpidemiología genética de la artritis reumatoide: qué esperar de América Latina?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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