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Vaccination with recombinant Plasmodium vivax MSP-10 formulated in different adjuvants induces strong immunogenicity but no protection

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dc.creatorGiraldo, Manuel A.spa
dc.creatorArevalo-Pinzon, Gabrielaspa
dc.creatorRojas-Caraballo, Josespa
dc.creatorMongui, Alvarospa
dc.creatorRodriguez, Raulspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:02:09Z
dc.date.available2020-05-26T00:02:09Z
dc.date.created2009spa
dc.description.abstractAlthough largely considered benign, Plasmodium vivax causes disease in nearly 75 million people each year and the available strategies are not sufficient to reduce the burden of disease, therefore pointing to vaccine development as a cost-effective control measure. In this study, the P. vivax merozoite surface protein 10 (MSP-10) was expressed as a recombinant protein in Escherichia coli and purified by affinity chromatography. High antigenicity was observed since sera from P. vivax-infected patients strongly recognized rPvMSP10. The immunogenicity of rPvMSP10 was tested in Aotus monkeys, comparing responses induced by formulations with Freund's adjuvant, Montanide ISA720 or aluminum hydroxide. All formulations produced high antibody titers recognizing the native protein in late schizonts. Despite inducing strong antibody production, none of the formulations protected immunized Aotus monkeys upon experimental challenge. © 2009 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2009.09.046
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23453
dc.language.isoengspa
dc.relation.citationEndPage13
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage7
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 28
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.28, No.1 (2009); pp. 7-13spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70649115450&doi=10.1016%2fj.vaccine.2009.09.046&partnerID=40&md5=ef33b246dba86a7d95eaad963df9037aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdjuvantspa
dc.subject.keywordprotozoaneng
dc.subject.keywordAntibodyspa
dc.subject.keywordChloroquinespa
dc.subject.keywordEmulsifying agentspa
dc.subject.keywordFreund adjuvantspa
dc.subject.keywordMontanide isa720spa
dc.subject.keywordProteinspa
dc.subject.keywordRecombinant merozoite surface protein 10spa
dc.subject.keywordRecombinant proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdjuvant therapyspa
dc.subject.keywordAffinity chromatographyspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAotusspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug antigenicityspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug formulationspa
dc.subject.keywordImmunityspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalariaspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordProtein purificationspa
dc.subject.keywordSchizontspa
dc.subject.keywordSerumspa
dc.subject.keywordVaccinationspa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntigenseng
dc.subject.keywordAotus trivirgatusspa
dc.subject.keywordFreund's adjuvantspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordMannitolspa
dc.subject.keywordOleic acidsspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordRecombinant proteinsspa
dc.subject.keywordAdjuvantsspa
dc.subject.keywordMerozoite surface proteins (msps)spa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordVaccinespa
dc.titleVaccination with recombinant Plasmodium vivax MSP-10 formulated in different adjuvants induces strong immunogenicity but no protectionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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