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Analysis of cognitive decline in patients with Huntington's disease using unified Huntington's disease rating scale

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dc.creatorBoll M.-C.spa
dc.creatorMartínez E.M.B.spa
dc.creatorOchoa A.spa
dc.creatorAlonso Ma.E.spa
dc.date.accessioned2020-05-25T23:58:27Z
dc.date.available2020-05-25T23:58:27Z
dc.date.created2008spa
dc.description.abstractPrevious to appearance of motor alterations in Huntington's disease (HD), there can be a discreet cognitive deterioration. During the first decade of evolution of the disease, Mini-Mental State Examination and IQ test may be normal and application of highly sensitive tests become necessary in prediction of anomalies. The cognitive deterioration of HD subjects with less than 10 years evolution was studied using the tests of Verbal Fluency, Symbol Digit Modalities and the entire 3 parts of the Stroop test. A transversal analysis in 61 subjects was employed to seek for correlations of results in these tests and time of evolution of disease and motor deterioration. In the 52 subjects that finished every subsequent evaluation, rates of six-month, yearly and eighteen-month change were estimated. All cognitive tests were significantly related to the motor subscale and time of evolution. Correlation of results in the Stroop test with motor scale produced a Pearson's correlation coefficient of -0.76 for word reading (part A), -0.68 for color naming (B) and -0.64 for interference test (C). Time of evolution was more highly related to the 2 remaining tests. The longitudinal study did not set in evidence any significant change with the exception of the quick reading section of Stroop A test, which showed 7 points deterioration in 18 months. This test turned out to be more sensitive than the other complex tasks for detection of any deterioration. ©INNN, 2008.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn10285938
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22866
dc.language.isoengspa
dc.relation.citationEndPage30
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage25
dc.relation.citationTitleArchivos de Neurociencias
dc.relation.citationVolumeVol. 13
dc.relation.ispartofArchivos de Neurociencias, ISSN:10285938, Vol.13, No.1 (2008); pp. 25-30spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-45549098678&partnerID=40&md5=eae0903ba01ee2a139f5278921be6b65spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCognitive defectspa
dc.subject.keywordControlled studyspa
dc.subject.keywordHumanspa
dc.subject.keywordHuntington choreaspa
dc.subject.keywordIntelligence quotientspa
dc.subject.keywordIntelligence testspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMental deteriorationspa
dc.subject.keywordRating scalespa
dc.subject.keywordReadingspa
dc.subject.keywordWord recognitionspa
dc.subject.keywordCognitionspa
dc.subject.keywordHuntington's diseasespa
dc.subject.keywordStroop interference testspa
dc.titleAnalysis of cognitive decline in patients with Huntington's disease using unified Huntington's disease rating scalespa
dc.title.TranslatedTitleAnálisis del deterioro cognoscitivo en pacientes con enfermedad de Huntington mediante las pruebas de la escala unificada (UHDRS)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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