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Use of anticonvulsive drugs during pregnancy and the risk of malformations in the newborn: A meta-analysis

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dc.creatorGutiérrez-Álvarez, Á. M.spa
dc.date.accessioned2020-06-11T13:22:18Z
dc.date.available2020-06-11T13:22:18Z
dc.date.created2003spa
dc.description.abstractObjective. To determine the risk, if any, of anticonvulsants use on the foetus with respect to major malformations. Materials and methods. MEDLINE, EMBASE, SCISEARCH and programs as ProQuest, HINARI y Ovid were searched for human studies. Studies that examined the effects of systematic exposure to any anticonvulsant during pregnancy (any dose, any duration, indicated for any type of epilepsy) were eligible. Studies that assessed major malformations in the infants were eligible. Major malformations were defined using the criteria described by Holmes. The number of neonates exposed to anticonvulsants who did and did not exhibit major malformations, and the number of neonates not exposed to anticonvulsants who did and did not exhibit major malformations, were extracted in the form of 2 × 2 tables. The odds ratio (OR), relative risk and 95% confidence interval (CI) was calculated for each of the studies. Results. Ten cohort studies and four case-control studies were included. A total of 2,509 cases and 433,890 controls were included. Major malformations were found in 9,8% among the exposed children and 7,4% among the non exposed. (OR: 2,7; CI 95%: 2.062-3.641; p < 0.000). There was no evidence of an association between any anticonvulsant and a specific major malformation. Conclusions. The available epidemiological data support the hypothesis that anticonvulsants increase the risk of major malformations by an order of 2- to 3-fold.spa
dc.format.mimetypeapplication/pdf
dc.identifier.issn2100010
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25085
dc.language.isospa
dc.publisherRevista de Neurologiaspa
dc.relation.citationEndPage1028
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage1022
dc.relation.citationTitleRevista de Neurologia
dc.relation.citationVolumeVol. 37
dc.relation.ispartofRevista de Neurologia, ISSN:2100010, Vol.37, No.11 (2003); pp. 1022-1028spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0347753308&partnerID=40&md5=dd34f4a68d7b6597669c79dac49d56e8spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnticonvulsive agentspa
dc.subject.keywordCarbamazepinespa
dc.subject.keywordFelbamatespa
dc.subject.keywordGabapentinspa
dc.subject.keywordLamotriginespa
dc.subject.keywordOxcarbazepinespa
dc.subject.keywordPhenobarbitalspa
dc.subject.keywordPhenytoinspa
dc.subject.keywordValproic acidspa
dc.subject.keywordVigabatrinspa
dc.subject.keywordArticlespa
dc.subject.keywordCardiovascular malformationspa
dc.subject.keywordCentral nervous system malformationspa
dc.subject.keywordCongenital malformationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDigestive system malformationspa
dc.subject.keywordEmbasespa
dc.subject.keywordEpilepsyspa
dc.subject.keywordFemalespa
dc.subject.keywordHigh risk patientspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMedlinespa
dc.subject.keywordPregnancyspa
dc.subject.keywordPrenatal exposurespa
dc.subject.keywordScisearchspa
dc.subject.keywordSkeleton malformationspa
dc.subject.keywordTeratogenicityspa
dc.subject.keywordUrinary tract malformationspa
dc.subject.keywordAbnormalitiesspa
dc.subject.keyworddrug-inducedspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInfantspa
dc.subject.keywordnewbornspa
dc.subject.keywordPregnancyspa
dc.subject.keywordPregnancy complicationsspa
dc.subject.keywordPrenatal exposure delayed effectsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordPregnancy complicationsspa
dc.subject.keywordPrenatal exposure delayed effectsspa
dc.titleUse of anticonvulsive drugs during pregnancy and the risk of malformations in the newborn: A meta-analysisspa
dc.title.TranslatedTitleUso de anticonvulsionantes durante el embarazo y riesgo de malformaciones en el recién nacido: Metanálisisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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