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Gastrointestinal-associated autoantibodies in different autoimmune diseases

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dc.creatorAnaya, Juan-Manuel
dc.creatorBizzaro, Nicolasspa
dc.creatorTincani, Angelaspa
dc.creatorEspinosa, Gerardspa
dc.creatorVillalta, Danilospa
dc.creatorCervera, Ricardspa
dc.date.accessioned2020-08-19T14:43:45Z
dc.date.available2020-08-19T14:43:45Z
dc.date.created2012-05-25spa
dc.description.abstractBackground: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID. Methods: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA). Results: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn’s disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn’s disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves’ disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients. Conclusions: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnEISSN: 2164-7712
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27765
dc.language.isoengspa
dc.publisherNational Library of Medicinespa
dc.relation.citationEndPage55
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage49
dc.relation.citationTitleAmerican Journal of Clinical and Experimental Immunology
dc.relation.citationVolumeVol. 1
dc.relation.ispartofAmerican Journal of Clinical and Experimental Immunology, EISSN: 2164-7712, Vol.1, No.1 (2012); pp. 49–55.spa
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714189/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceAmerican Journal of Clinical and Experimental Immunologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordGliadin (AGA)spa
dc.subject.keywordTissue-transglutaminase (tTG)spa
dc.subject.keywordSaccharomyces cerevisiae (ASCA)spa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordInflammatory bowel diseases.spa
dc.titleGastrointestinal-associated autoantibodies in different autoimmune diseasesspa
dc.title.TranslatedTitleAutoanticuerpos asociados al tubo digestivo en diferentes enfermedades autoinmunesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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