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Cost effectiveness of strategies to combat chronic obstructive pulmonary disease and asthma in sub-Saharan Africa and South East Asia: mathematical modelling study

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dc.creatorStanciole, Anderson Espa
dc.creatorOrtegón, Mónicaspa
dc.creatorChisholm, Danspa
dc.creatorLauer, Jeremy Aspa
dc.date.accessioned2020-08-06T16:20:39Z
dc.date.available2020-08-06T16:20:39Z
dc.date.created2012-03-02spa
dc.description.abstractObjectives To determine the population level costs, effects, and cost effectiveness of selected, individual based interventions to combat chronic obstructive pulmonary disease (COPD) and asthma in the context of low and middle income countries. Design Sectoral cost effectiveness analysis using a lifetime population model. Setting Two World Health Organization sub-regions of the world: countries in sub-Saharan Africa with very high adult and high child mortality (AfrE); and countries in South East Asia with high adult and high child mortality (SearD). Data sources Disease rates and profiles were taken from the WHO Global Burden of Disease study; estimates of intervention effects and resource needs were drawn from clinical trials, observational studies, and treatment guidelines. Unit costs were taken from a WHO price database. Main outcome measures Cost per disability adjusted life year (DALY) averted, expressed in international dollars ($Int) for the year 2005. Results In both regions low dose inhaled corticosteroids for mild persistent asthma was considered the most cost effective intervention, with average cost per DALY averted about $Int2500. The next best value strategies were influenza vaccine for COPD in Sear-D (incremental cost $Int4950 per DALY averted) and low dose inhaled corticosteroids plus long acting ? agonists for moderate persistent asthma in Afr-E (incremental cost $Int9112 per DALY averted). Conclusions COPD is irreversible and progressive, and current treatment options produce relatively little gains relative to the cost. The treatment options available for asthma, however, generally decrease chronic respiratory disease burden at a relatively low cost.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/bmj.e608
dc.identifier.issnISSN: 0959-8138
dc.identifier.issnEISSN: 2044-6055
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26092
dc.language.isoengspa
dc.publisherBMJ Publishing Groupspa
dc.relation.citationIssueNo. 21
dc.relation.citationStartPagee608
dc.relation.citationTitleBMJ British Medical Journal
dc.relation.citationVolumeVol. 344
dc.relation.ispartofBMJ, ISSN: 0959-8138 ; EISSN: 2044-6055, Vol.344, No.21 (2012-03-02); pp.e608spa
dc.relation.urihttps://www.bmj.com/content/344/bmj.e608.full.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceBMJ British Medical Journalspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAfrica South of the Saharaspa
dc.subject.keywordAgedspa
dc.subject.keywordAgedspa
dc.subject.keyword80 and overspa
dc.subject.keywordAsiaspa
dc.subject.keywordSoutheasternspa
dc.subject.keywordAsthmaspa
dc.subject.keywordChildspa
dc.subject.keywordChildspa
dc.subject.keywordPreschoolspa
dc.subject.keywordCost-Benefit Analysisspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordModelsspa
dc.subject.keywordTheoreticalspa
dc.subject.keywordPulmonary Diseasespa
dc.subject.keywordChronic Obstructivespa
dc.subject.keywordYoung Adultspa
dc.titleCost effectiveness of strategies to combat chronic obstructive pulmonary disease and asthma in sub-Saharan Africa and South East Asia: mathematical modelling studyspa
dc.title.TranslatedTitleRentabilidad de las estrategias para combatir la enfermedad pulmonar obstructiva crónica y el asma en el África subsahariana y el sudeste asiático: estudio de modelos matemáticosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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