Ítem
Desconocido

Hyperprocalcitonemia and Endothelial and Microcirculatory Dysfunction in Children With Sepsis and Septic Shock: Single-Center Observational Cohort Study in Colombia, 2021–2024

Mostrar el registro sencillo de la publicación
dc.contributor.otherAguirre Gutierrez, Valeria
dc.contributor.otherNiño Ariza, Maria Carolina
dc.contributor.otherBernal Sierra, Tatiana
dc.contributor.otherCabezas Rosas, Marisol
dc.creatorBeltrán Hernández, Briam
dc.creatorFernández-Sarmiento, Jaime
dc.creatorMullet, Hernando
dc.creatorNiño Ariza, Maria Carolina
dc.creatorAguirre Gutierrez, Valeria
dc.creatorCárdenas, Carolina
dc.creatorCardona, María Paula
dc.creatorBernal Sierra, Tatiana
dc.creatorCabezas Rosas, Marisol
dc.creatorGarzón Angel, Lina
dc.creatorSarta, Mauricio
dc.creatorFernández-Sarta, Juan Pablo
dc.creatorLa Rotta, Isabella
dc.creatorBuelvas-Pérez, Juanita
dc.creatorRodriguez, Laura Sofia
dc.creatorBarrera Suárez, Maria José
dc.creatorKissoon, Niranjan
dc.date.accessioned2025-07-14T17:20:21Z
dc.date.available2025-07-14T17:20:21Z
dc.date.created2025-06-25
dc.date.issued2025-06-25
dc.descriptionOBJECTIVES: To evaluate the association between hyperprocalcitonemia and endothelial and microcirculatory dysfunction in children with sepsis and septic shock and clinical outcomes. DESIGN: A prospective observational cohort study, 2021–2024. SETTING: A tertiary PICU with 15 medical-surgical beds in a university hospital. PATIENTS: We included children with sepsis and/or septic shock who had serum procalcitonin measured at admission, 24 hours, and 48 hours, simultaneously with microcirculatory assessment using sublingual videomicroscopy and biomarkers of endothelial injury (syndecan-1, angiopoietin-2, and endocan). Hyperprocalcitonemia was defined as procalcitonin greater than 2ng/mL. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: In 230 patients, 43.9% (101/230) had hyperprocalcitonemia at PICU admission. After adjusting for confounders, children with hyperprocalcitonemia, compared with those with normal procalcitonin, had higher adjusted odds ratio (aOR [95% CI]) of reduced capillary blood flow at 24 hours (aOR, 1.35 [95% CI, 1.08–1.72]) and 48 hours (aOR, 1.14 [95%CI, 1.04–1.24]) after admission. At 24 hours, children with hyperprocalcitonemia compared with those without hyperprocalcitonemia had higher median (interquartile range [IQR]) syndecan-1 levels (125.87ng/mL [IQR, 49.56–224.30ng/mL] vs. 107.71ng/mL [IQR, 62.82–156.55ng/mL], respectively; p < 0.01) and greater odds of angiopoietin-2 elevation (aOR, 2.28 [95% CI, 1.08–5.17]; p = 0.042). Hyperprocalcitonemia with severe endothelial/microcirculatory dysfunction was associated with fluid overload greater than 10% (aOR, 2.01 [95% CI, 1.06– 3.80]; p = 0.033), multiple organ dysfunction (aOR, 1.87 [95% CI, 1.01–3.57]; p = 0.041), and mortality (aOR, 1.66 [95% CI, 1.06–2.61]; p = 0.022). We failed to identify differences in capillary density (4–6 µm), angiopoietin-2, or Endocan between children with and without hyperprocalcitonemia at PICU admission. CONCLUSIONS: Children with sepsis and septic shock with hyperprocalcitonemia represent a phenotype characterized by endothelial and microvascular dysfunction, which is associated with worse clinical outcomes. Our study suggests that preserving microvascular integrity may be a therapeutic target to reduce microcirculatory damage and improve outcomes.
dc.description.abstractOBJECTIVES: To evaluate the association between hyperprocalcitonemia and endothelial and microcirculatory dysfunction in children with sepsis and septic shock and clinical outcomes. DESIGN: A prospective observational cohort study, 2021–2024. SETTING: A tertiary PICU with 15 medical-surgical beds in a university hospital. PATIENTS: We included children with sepsis and/or septic shock who had serum procalcitonin measured at admission, 24 hours, and 48 hours, simultaneously with microcirculatory assessment using sublingual videomicroscopy and biomarkers of endothelial injury (syndecan-1, angiopoietin-2, and endocan). Hyperprocalcitonemia was defined as procalcitonin greater than 2ng/mL. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: In 230 patients, 43.9% (101/230) had hyperprocalcitonemia at PICU admission. After adjusting for confounders, children with hyperprocalcitonemia, compared with those with normal procalcitonin, had higher adjusted odds ratio (aOR [95% CI]) of reduced capillary blood flow at 24 hours (aOR, 1.35 [95% CI, 1.08–1.72]) and 48 hours (aOR, 1.14 [95%CI, 1.04–1.24]) after admission. At 24 hours, children with hyperprocalcitonemia compared with those without hyperprocalcitonemia had higher median (interquartile range [IQR]) syndecan-1 levels (125.87ng/mL [IQR, 49.56–224.30ng/mL] vs. 107.71ng/mL [IQR, 62.82–156.55ng/mL], respectively; p < 0.01) and greater odds of angiopoietin-2 elevation (aOR, 2.28 [95% CI, 1.08–5.17]; p = 0.042). Hyperprocalcitonemia with severe endothelial/microcirculatory dysfunction was associated with fluid overload greater than 10% (aOR, 2.01 [95% CI, 1.06– 3.80]; p = 0.033), multiple organ dysfunction (aOR, 1.87 [95% CI, 1.01–3.57]; p = 0.041), and mortality (aOR, 1.66 [95% CI, 1.06–2.61]; p = 0.022). We failed to identify differences in capillary density (4–6 µm), angiopoietin-2, or Endocan between children with and without hyperprocalcitonemia at PICU admission. CONCLUSIONS: Children with sepsis and septic shock with hyperprocalcitonemia represent a phenotype characterized by endothelial and microvascular dysfunction, which is associated with worse clinical outcomes. Our study suggests that preserving microvascular integrity may be a therapeutic target to reduce microcirculatory damage and improve outcomes.
dc.format.extent10 pp
dc.format.mimetypeapplication/pdf
dc.geoLocationBogotá, Colombia
dc.identifier.doihttps://doi.org/10.1097/PCC.0000000000003782
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/45876
dc.language.isospa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.source.bibliographicCitationDahabreh, Issa J.; Bibbins-Domingo, Kirsten (2024) Causal Inference About the Effects of Interventions From Observational Studies in Medical Journals. En: JAMA. Vol. 331; No. 21; pp. 1845 - 1845; Disponible en: 10.1001/jama.2024.7741.
dc.source.bibliographicCitationAldewereld, Zachary; Horvat, Christopher; Clermont, Gilles (2025) Pediatric Sepsis Phenotype in a Single-Center Cohort Covering 2010–2020: Evolution in Day 1–Day 3 Trajectory and Potential Prognostic Value. En: Pediatric Critical Care Medicine. Vol. 26; No. 7; pp. e909 - e914; Disponible en: 10.1097/PCC.0000000000003708.
dc.source.bibliographicCitationStanski, Natalja L.; Zhang, Bin; Cvijanovich, Natalie Z.; Fitzgerald, Julie C.; Bigham, Michael T.; Jain, Parag N.; Schwarz, Adam J.; Lutfi, Riad; Allen, Geoffrey L.; Thomas, Neal J.; Baines, Torrey; Haileselassie, Bereketeab; Weiss, Scott L.; Atreya, Mihir R.; Lautz, Andrew J.; Zingarelli, Basilia; Standage, Stephen W.; Kaplan, Jennifer; Goldstein, Stuart L. (2024) Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock*. En: Pediatric Critical Care Medicine. Vol. 25; No. 11; pp. 1005 - 1016; Disponible en: 10.1097/PCC.0000000000003589.
dc.source.bibliographicCitationAtreya, Mihir R.; Bennett, Tellen D.; Geva, Alon; Faustino, E. Vincent S.; Rogerson, Colin M.; Lutfi, Riad; Cvijanovich, Natalie Z.; Bigham, Michael T.; Nowak, Jeffrey; Schwarz, Adam J.; Baines, Torrey; Haileselassie, Bereketeab; Thomas, Neal J.; Luo, Yuan; Sanchez-Pinto, L. Nelson (2024) Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. En: Pediatric Critical Care Medicine. Vol. 25; No. 6; pp. 512 - 517; Disponible en: 10.1097/PCC.0000000000003499.
dc.source.bibliographicCitationSanchez-Pinto, L. Nelson; Bennett, Tellen D.; Stroup, Emily K.; Luo, Yuan; Atreya, Mihir; Bubeck Wardenburg, Juliane; Chong, Grace; Geva, Alon; Faustino, E. Vincent S.; Farris, Reid W.; Hall, Mark W.; Rogerson, Colin; Shah, Sareen S.; Weiss, Scott L.; Khemani, Robinder G. (2023) Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. En: Pediatric Critical Care Medicine. Vol. 24; No. 10; pp. 795 - 806; Disponible en: 10.1097/PCC.0000000000003292.
dc.source.bibliographicCitationBranco, Ricardo G. (2023) Balancing Fluid Resuscitation in Pediatric Sepsis*. En: Pediatric Critical Care Medicine. Vol. 24; No. 3; pp. 257 - 259; Disponible en: 10.1097/PCC.0000000000003172.
dc.source.bibliographicCitationNylen, Eric S.; Whang, Kevin T.; Snider, Richard H.; Steinwald, Paul M.; White, Jon C.; Becker, Kenneth L. (1998) Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. En: Critical Care Medicine. Vol. 26; No. 6; pp. 1001 - 1006; Disponible en: 10.1097/00003246-199806000-00015.
dc.source.bibliographicCitationDuranteau, J.; De Backer, D.; Donadello, K.; Shapiro, N. I.; Hutchings, S. D.; Rovas, A.; Legrand, M.; Harrois, A.; Ince, C. (2023) The future of intensive care: the study of the microcirculation will help to guide our therapies. En: Critical Care. Vol. 27; No. 1; pp. 190 - 190; Disponible en: 10.1186/s13054-023-04474-x.
dc.source.bibliographicCitationPiotti, Arianna; Novelli, Deborah; Meessen, Jennifer Marie Theresia Anna; Ferlicca, Daniela; Coppolecchia, Sara; Marino, Antonella; Salati, Giovanni; Savioli, Monica; Grasselli, Giacomo; Bellani, Giacomo; Pesenti, Antonio; Masson, Serge; Caironi, Pietro; Gattinoni, Luciano; Gobbi, Marco; Fracasso, Claudia; Latini, Roberto; Bruzzone, Paola; Pagan, Francesca; Russo, Riccarda; Confalonieri, Andrea; Abbruzzese, Chiara; Vergnano, Beatrice; Faenza, Stefano; Siniscalchi, Antonio; Pierucci, Elisabetta; Noto, Andrea; Pezzi, Angelo; Spanu, Paolo; Parrini, Vieri; Oggioni, Roberto; Pasetti, Giovanni Stefano; Casadio, Maria Cinzia; Buontempo, Rosa; Carrer, Sara; Piccoli, Francesca; Rizzi, Tatiana; Caricato, Anselmo; La Sala, Monica; Antonaci, Alessandra; Fassini, Paola; Paganini, Silvia; Porta, Virginia; Moise, Gabriella; Marell, Silvia; Furia, Mirella; Urbano, Maria Cristina; Carobbi, Roberta; Poleni, Simona; Kandil, Hassan; Ballotta, Andrea; Bettini, Fabrizio; Sanseverino, Manlio; Gatta, Alessandro; Cecchini, Francesca; Guatteri, Luca; Ciceri, Gabriella; Raimondi, Ferdinando; Colombo, Roberto; Ferraris, Sandra; Borelli, Massimo; Bellato, Valentina; Cancellieri, Franco; Senni, Silvia; Bertocchi, Ester; Ferri, Paola; Moioli, Gianpietro; Fedele, Andrea; Molin, Alexandra; Salati, Giovanni; Salsi, Pierpaolo; Brunori, Emanuela; Elisei, Daniele; Maggio, Giuseppe; Nicola, Federico Guardia; Cavana, Marco; Morelli, Giacomo; Guarino, Arturo; Isetta, Michele; Tulli, Giorgio; Mangani, Valerio; Rossi, Nicola; Ferrari, Marta; Bona, Francesco; Vay, Monica; Bartoli, Teresa; Gallo, Mauro; Vettoretto, Katiuscia; Morte, Mauro Della; Boselli, Enrico; Puscio, Daniela; Bovo, Monia; Galzerano, Antonio; Carli, Manuela; Zagara, Giovanni (2021) Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS. En: Critical Care. Vol. 25; No. 1; pp. 113 - 113; Disponible en: 10.1186/s13054-021-03545-1.
dc.source.bibliographicCitationInce, Can (2015) Hemodynamic coherence and the rationale for monitoring the microcirculation. En: Critical Care. Vol. 19; No. S3; pp. S8 - S8; Disponible en: 10.1186/cc14726.
dc.source.bibliographicCitationBaranowsky, Anke; Appelt, Jessika; Kleber, Christian; Lange, Tobias; Ludewig, Peter; Jahn, Denise; Pandey, Puja; Keller, Daniela; Rose, Thomas; Schetler, Daniela; Braumüller, Sonja; Huber-Lang, Markus; Tsitsilonis, Serafeim; Yorgan, Timur; Frosch, Karl-Heinz; Amling, Michael; Schinke, Thorsten; Keller, Johannes (2021) Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor. En: Critical Care Medicine. Vol. 49; No. 1; pp. e41 - e52; Disponible en: 10.1097/CCM.0000000000004731.
dc.source.bibliographicCitationOpal, S. M.; van der Poll, T. (2015) Endothelial barrier dysfunction in septic shock. En: Journal of Internal Medicine. Vol. 277; No. 3; pp. 277 - 293; Disponible en: 10.1111/joim.12331.
dc.source.bibliographicCitationHellenthal, Katharina E. M.; Brabenec, Laura; Wagner, Nana-Maria (2022) Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation. En: Cells. Vol. 11; No. 12; pp. 1935 - 1935; Disponible en: 10.3390/cells11121935.
dc.source.bibliographicCitationØstergaard, Leif (2020) Blood flow, capillary transit times, and tissue oxygenation: the centennial of capillary recruitment. En: Journal of Applied Physiology. Vol. 129; No. 6; pp. 1413 - 1421; Disponible en: 10.1152/japplphysiol.00537.2020.
dc.source.bibliographicCitationGupta, Shefali; Jaswani, Pradeep; Sharma, Raj K.; Agrawal, Suraksha; Prasad, Narayan; Sahu, Chinmoy; Gupta, Amit; Prasad, Kashi N. (2019) Procalcitonin as a diagnostic biomarker of sepsis: A tertiary care centre experience. En: Journal of Infection and Public Health. Vol. 12; No. 3; pp. 323 - 329; Disponible en: 10.1016/j.jiph.2018.11.004.
dc.source.bibliographicCitationBecker, Kenneth L.; Snider, Richard; Nylen, Eric S. (2010) Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. En: British Journal of Pharmacology. Vol. 159; No. 2; pp. 253 - 264; Disponible en: 10.1111/j.1476-5381.2009.00433.x.
dc.source.bibliographicCitationSinha, Mahua; Desai, Seemanthini; Mantri, Sumant; Kulkarni, Anuja (2011) Procalcitonin as an adjunctive biomarker in sepsis. En: Indian Journal of Anaesthesia. Vol. 55; No. 3; pp. 266 - 266; Disponible en: 10.4103/0019-5049.82676.
dc.source.bibliographicCitationRovas, Alexandros; Sackarnd, Jan; Rossaint, Jan; Kampmeier, Stefanie; Pavenstädt, Hermann; Vink, Hans; Kümpers, Philipp (2021) Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. En: Critical Care. Vol. 25; No. 1; pp. 112 - 112; Disponible en: 10.1186/s13054-021-03520-w.
dc.source.bibliographicCitationRovas, Alexandros; Lukasz, Alexander-Henrik; Vink, Hans; Urban, Marc; Sackarnd, Jan; Pavenstädt, Hermann; Kümpers, Philipp (2018) Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study. En: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. Vol. 26; No. 1; pp. 16 - 16; Disponible en: 10.1186/s13049-018-0483-4.
dc.source.bibliographicCitationInce, Can; Boerma, E. Christiaan; Cecconi, Maurizio; De Backer, Daniel; Shapiro, Nathan I.; Duranteau, Jacques; Pinsky, Michael R.; Artigas, Antonio; Teboul, Jean-Louis; Reiss, Irwin K. M.; Aldecoa, Cesar; Hutchings, Sam D.; Donati, Abele; Maggiorini, Marco; Taccone, Fabio S.; Hernandez, Glenn; Payen, Didier; Tibboel, Dick; Martin, Daniel S.; Zarbock, Alexander; Monnet, Xavier; Dubin, Arnaldo; Bakker, Jan; Vincent, Jean-Louis; Scheeren, Thomas W. L. (2018) Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. En: Intensive Care Medicine. Vol. 44; No. 3; pp. 281 - 299; Disponible en: 10.1007/s00134-018-5070-7.
dc.source.bibliographicCitationBecker, Bernhard F.; Jacob, Matthias; Leipert, Stephanie; Salmon, Andrew H. J.; Chappell, Daniel (2015) Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases. En: British Journal of Clinical Pharmacology. Vol. 80; No. 3; pp. 389 - 402; Disponible en: 10.1111/bcp.12629.
dc.source.bibliographicCitationHou, Peter C.; Filbin, Michael R.; Wang, Henry; Ngo, Long; Huang, David T.; Aird, William C.; Yealy, Donald M.; Angus, Derek C.; Kellum, John A.; Shapiro, Nathan I. (2017) Endothelial Permeability and Hemostasis in Septic Shock. En: Chest. Vol. 152; No. 1; pp. 22 - 31; Disponible en: 10.1016/j.chest.2017.01.010.
dc.source.bibliographicCitationShapiro, Nathan I; Schuetz, Philipp; Yano, Kiichiro; Sorasaki, Midori; Parikh, Samir M; Jones, Alan E; Trzeciak, Stephen; Ngo, Long; Aird, William C (2010) The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. En: Critical Care. Vol. 14; No. 5; pp. R182 - R182; Disponible en: 10.1186/cc9290.
dc.source.bibliographicCitationEdul, Vanina S. Kanoore; Ince, Can; Vazquez, Alejandro Risso; Rubatto, Paolo N.; Espinoza, Emilio D. Valenzuela; Welsh, Sebastián; Enrico, Carolina; Dubin, Arnaldo (2016) Similar Microcirculatory Alterations in Patients with Normodynamic and Hyperdynamic Septic Shock. En: Annals of the American Thoracic Society. Vol. 13; No. 2; pp. 240 - 247; Disponible en: 10.1513/AnnalsATS.201509-606OC.
dc.source.bibliographicCitationPoole, David C.; Pittman, Roland N.; Musch, Timothy I.; Østergaard, Leif (2020) August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data. En: The Journal of Physiology. Vol. 598; No. 20; pp. 4473 - 4507; Disponible en: 10.1113/JP279223.
dc.source.bibliographicCitationDe Backer, Daniel; Orbegozo Cortes, Diego; Donadello, Katia (2014) Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock. En: Virulence. Vol. 5; No. 1; pp. 73 - 79; Disponible en: 10.4161/viru.26482.
dc.source.bibliographicCitationSchlapbach, Luregn J.; Watson, R. Scott; Sorce, Lauren R.; Argent, Andrew C.; Menon, Kusum; Hall, Mark W.; Akech, Samuel; Albers, David J.; Alpern, Elizabeth R.; Balamuth, Fran; Bembea, Melania; Biban, Paolo; Carrol, Enitan D.; Chiotos, Kathleen; Chisti, Mohammod Jobayer; Dewitt, Peter E.; Evans, Idris; Flauzino De Oliveira, Cláudio; Horvat, Christopher M.; Inwald, David; Ishimine, Paul; Jaramillo-Bustamante, Juan Camilo; Levin, Michael; Lodha, Rakesh; Martin, Blake; Nadel, Simon; Nakagawa, Satoshi; Peters, Mark J.; Randolph, Adrienne G.; Ranjit, Suchitra; Rebull, Margaret N.; Russell, Seth; Scott, Halden F.; De Souza, Daniela Carla; Tissieres, Pierre; Weiss, Scott L.; Wiens, Matthew O.; Wynn, James L.; Kissoon, Niranjan; Zimmerman, Jerry J.; Sanchez-Pinto, L. Nelson; Bennett, Tellen D. (2024) International Consensus Criteria for Pediatric Sepsis and Septic Shock. En: JAMA.: American Medical Association; Disponible en: 10.1001/jama.2024.0179.
dc.source.bibliographicCitationDownes, Kevin J.; Fitzgerald, Julie C.; Weiss, Scott L. (2020) Utility of Procalcitonin as a Biomarker for Sepsis in Children. En: Journal of Clinical Microbiology. Vol. 58; No. 7; American Society for Microbiology; Disponible en: 10.1128/JCM.01851-19.
dc.source.bibliographicCitationFernández-Sarmiento, Jaime; Lamprea, Shirley; Barrera, Sofia; Acevedo, Lorena; Duque, Catalina; Trujillo, Manuela; Aguirre, Valeria; Jimenez, Carolina (2024) The association between prolonged capillary refill time and microcirculation changes in children with sepsis. En: BMC Pediatrics. Vol. 24; No. 1; pp. 68 - 68; Disponible en: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-04524-5. Disponible en: 10.1186/s12887-024-04524-5.
dc.source.bibliographicCitationFernández-Sarmiento, Jaime; Salazar-Peláez, Lina María; Carcillo, Joseph A. (2020) The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis. En: Pediatric Critical Care Medicine. Vol. 21; No. 5; pp. E291 - E300; Lippincott Williams and Wilkins; Disponible en: 10.1097/PCC.0000000000002266.
dc.source.bibliographicCitationWeiss, Scott L.; Peters, Mark J.; Alhazzani, Waleed; Agus, Michael S.D.; Flori, Heidi R.; Inwald, David P.; Nadel, Simon; Schlapbach, Luregn J.; Tasker, Robert C.; Argent, Andrew C.; Brierley, Joe; Carcillo, Joseph; Carrol, Enitan D.; Carroll, Christopher L.; Cheifetz, Ira M.; Choong, Karen; Cies, Jeffry J.; Cruz, Andrea T.; De Luca, Daniele; Deep, Akash; Faust, Saul N.; De Oliveira, Claudio Flauzino; Hall, Mark W.; Ishimine, Paul; Javouhey, Etienne; Joosten, Koen F.M.; Joshi, Poonam; Karam, Oliver; Kneyber, Martin C.J.; Lemson, Joris; MacLaren, Graeme; Mehta, Nilesh M.; Møller, Morten Hylander; Newth, Christopher J.L.; Nguyen, Trung C.; Nishisaki, Akira; Nunnally, Mark E.; Parker, Margaret M.; Paul, Raina M.; Randolph, Adrienne G.; Ranjit, Suchitra; Romer, Lewis H.; Scott, Halden F.; Tume, Lyvonne N.; Verger, Judy T.; Williams, Eric A.; Wolf, Joshua; Wong, Hector R.; Zimmerman, Jerry J.; Kissoon, Niranjan; Tissieres, Pierre (2020) Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. En: Intensive Care Medicine. Vol. 46; pp. 10 - 67; Springer; Disponible en: 10.1007/s00134-019-05878-6.
dc.source.bibliographicCitationFernández-Sarmiento, Jaime; Salazar-Peláez, Lina María; Acevedo, Lorena; Niño-Serna, Laura Fernanda; Flórez, Steffanie; Alarcón-Forero, Laura; Mulett, Hernando; Gómez, Laura; Villar, Juan Carlos (2023) Endothelial and Glycocalyx Biomarkers in Children With Sepsis After One Bolus of Unbalanced or Balanced Crystalloids*. En: Pediatric Critical Care Medicine. Vol. 24; No. 3; pp. 213 - 221; Lippincott Williams and Wilkins; Disponible en: 10.1097/PCC.0000000000003123.
dc.source.bibliographicCitationWagner, Nana Maria; Van Aken, Caroline; Butschkau, Antje; Bierhansl, Laura; Kellner, Patrick; Schleusener, Viola; Seggewiss, Jochen; Vollmar, Brigitte; Nöldge-Schomburg, Gabriele; Roesner, Jan Patrick (2017) Procalcitonin Impairs Endothelial Cell Function and Viability. En: Anesthesia and Analgesia. Vol. 124; No. 3; pp. 836 - 845; Lippincott Williams and Wilkins; Disponible en: 10.1213/ANE.0000000000001574.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectEndothelium
dc.subjectExtracellular matrix
dc.subjectOutcomes
dc.subjectProteoglycans
dc.subjectSepsis
dc.subjectVascular permeability
dc.subject.keywordEndothelium
dc.subject.keywordExtracellular matrix
dc.subject.keywordOutcomes
dc.subject.keywordProteoglycans
dc.subject.keywordSepsis
dc.subject.keywordVascular permeability
dc.titleHyperprocalcitonemia and Endothelial and Microcirculatory Dysfunction in Children With Sepsis and Septic Shock: Single-Center Observational Cohort Study in Colombia, 2021–2024
dc.typejournalArticle
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículo
Archivos
Bloque original
Mostrando1 - 2 de 2
Miniatura
Nombre:
Hyperprocalcitonemia_and_Endothelial_and_Microcirculatory_Dysfunction_in_Children_With_Sepsis_and_Septic_Shock_Single.pdf
Tamaño:
1.26 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Miniatura
Nombre:
Hyperprocalcitonemia_and_Endothelial_and_Microcirculatory.ris
Tamaño:
46.99 KB
Formato:
Descripción:
Descargar
Colecciones
Artículos