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Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease

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dc.creatorRuíz Sternberg, Ángela María
dc.creatorRuiz, Jaime Enriquespa
dc.creatorGavilanes, Andrés Velásquezspa
dc.creatorEriksson, Tiinaspa
dc.creatorLehtinen, Mattispa
dc.creatorPérez, Gonzalospa
dc.creatorSings, Heather L.spa
dc.creatorJames, Margaret K.spa
dc.creatorHaupt, Richard M.spa
dc.date.accessioned2020-05-25T23:56:15Z
dc.date.available2020-05-25T23:56:15Z
dc.date.created2012spa
dc.description.abstractBackground We assessed if risk of developing cervical intraepithelial neoplasia grade 2/3 (CIN2/3) or adenocarcinoma in situ (AIS) is associated with a short interval between menarche and first sexual intercourse (FSI).Methods A total of 1009 Colombian and 1012 Finnish females, aged 16-23, who were enrolled in the phase 3 trials of a quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccine had nonmissing data for age of menarche and FSI. The impact of menarche interval on the odds of developing CIN2-3/AIS was evaluated in placebo recipients who were DNA negative to HPV 6/11/16/18/31/33/35/39/45/51/52/56/58/59 and seronegative to HPV 6/11/16/18 at day 1, and had a normal Pap result at day 1 and month 7, thus approximating sexually naive adolescents (n = 504).Results The mean age of menarche and FSI was 12.4 and 16.0 years, respectively. Among the women approximating sexually naive adolescents, 18 developed CIN2-3/AIS. Compared with women who postponed FSI beyond 3 years of menarche, those with FSI within 3 years of menarche had a greater risk of cytologic abnormalities (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.02-2.68; P =. 04) and CIN2-3/AIS (OR, 3.56; 95% CI, 1.02-12.47; P =. 05).Conclusions A short interval between menarche and FSI was a risk factor for cytologic abnormalities and high-grade cervical disease. These data emphasize the importance of primary prevention through education and vaccination.Clinical Trials Registration. NCT00092521 and NCT00092534. © 2012 The Author.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jis612
dc.identifier.issn00221899
dc.identifier.issn15376613
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22376
dc.language.isoengspa
dc.relation.citationEndPage1896
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage1887
dc.relation.citationTitleJournal of Infectious Diseases
dc.relation.citationVolumeVol. 206
dc.relation.ispartofJournal of Infectious Diseases, ISSN:00221899, 15376613, Vol.206, No.12 (2012); pp. 1887-1896spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84870209754&doi=10.1093%2finfdis%2fjis612&partnerID=40&md5=6a6dfa0d40c17a98e55cffcbd8f70c79spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordOral contraceptive agentspa
dc.subject.keywordphase iii as topiceng
dc.subject.keywordVirus dnaspa
dc.subject.keywordWart virus vaccinespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCancer riskspa
dc.subject.keywordColombianspa
dc.subject.keywordColposcopyspa
dc.subject.keywordCondomspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordEthnic groupspa
dc.subject.keywordFemalespa
dc.subject.keywordFinnishspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman papillomavirus type 11spa
dc.subject.keywordHuman papillomavirus type 16spa
dc.subject.keywordHuman papillomavirus type 18spa
dc.subject.keywordHuman papillomavirus type 31spa
dc.subject.keywordHuman papillomavirus type 33spa
dc.subject.keywordHuman papillomavirus type 35spa
dc.subject.keywordHuman papillomavirus type 39spa
dc.subject.keywordHuman papillomavirus type 45spa
dc.subject.keywordHuman papillomavirus type 51spa
dc.subject.keywordHuman papillomavirus type 52spa
dc.subject.keywordHuman papillomavirus type 56spa
dc.subject.keywordHuman papillomavirus type 58spa
dc.subject.keywordHuman papillomavirus type 59spa
dc.subject.keywordHuman papillomavirus type 6spa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMenarchespa
dc.subject.keywordPapanicolaou testspa
dc.subject.keywordPhase 3 clinical trial (topic)spa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPost hoc analysisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSexual behaviorspa
dc.subject.keywordSexual intercoursespa
dc.subject.keywordUterine cervix biopsyspa
dc.subject.keywordUterine cervix carcinoma in situspa
dc.subject.keywordUterine cervix cytologyspa
dc.subject.keywordWart virusspa
dc.subject.keywordAdenocarcinomaspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordCervical intraepithelial neoplasiaspa
dc.subject.keywordClinical trialseng
dc.subject.keywordCoitusspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordFinlandspa
dc.subject.keywordHumansspa
dc.subject.keywordMenarchespa
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSexual behaviorspa
dc.subject.keywordTime factorsspa
dc.subject.keywordUterine cervical neoplasmsspa
dc.subject.keywordYoung adultspa
dc.titleProximity of first sexual intercourse to menarche and risk of high-grade cervical diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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