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Ebola virus disease: An emerging and re-emerging viral threat

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dc.creatorRojas Quintana, Manuel Eduardospa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Nieva, Yovana
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorAnsari, Aftab A.spa
dc.creatorGershwin, M. Ericspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:52Z
dc.date.available2020-05-25T23:55:52Z
dc.date.created2020spa
dc.description.abstractThe genus Ebolavirus from the family Filoviridae is composed of five species including Sudan ebolavirus, Reston ebolavirus, Bundibugyo ebolavirus, Taï Forest ebolavirus, and Ebola virus (previously known as Zaire ebolavirus). These viruses have a large non-segmented, negative-strand RNA of approximately 19 kb that encodes for glycoproteins (i.e., GP, sGP, ssGP), nucleoproteins, virion proteins (i.e., VP 24, 30,40) and an RNA dependent RNA polymerase. These viruses have become a global health concern because of mortality, their rapid dissemination, new outbreaks in West-Africa, and the emergence of a new condition known as “Post-Ebola virus disease syndrome” that resembles inflammatory and autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus and spondyloarthritis with uveitis. However, there are many gaps in the understanding of the mechanisms that may induce the development of such autoimmune-like syndromes. Some of these mechanisms may include a high formation of neutrophil extracellular traps, an uncontrolled “cytokine storm”, and the possible formation of auto-antibodies. The likely appearance of autoimmune phenomena in Ebola survivors suppose a new challenge in the management and control of this disease and opens a new field of research in a special subgroup of patients. Herein, the molecular biology, pathogenesis, clinical manifestations, and treatment of Ebola virus disease are reviewed and some strategies for control of disease are discussed. © 2019 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2019.102375
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22246
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 106
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.106,(2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85076205081&doi=10.1016%2fj.jaut.2019.102375&partnerID=40&md5=e8041ec994be679af482e6978857d430spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGlycoproteinspa
dc.subject.keywordNucleoproteinspa
dc.subject.keywordRna directed rna polymerasespa
dc.subject.keywordCarboxy terminal sequencespa
dc.subject.keywordDisease re-emergencespa
dc.subject.keywordEbola hemorrhagic feverspa
dc.subject.keywordEbolavirusspa
dc.subject.keywordExtracellular trapspa
dc.subject.keywordGene activationspa
dc.subject.keywordHost cellspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunosuppressive treatmentspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMolecular biologyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOverlapping genespa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRna bindingspa
dc.subject.keywordRna interferencespa
dc.subject.keywordSpondylarthritisspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTropismspa
dc.subject.keywordUveitisspa
dc.subject.keywordVirionspa
dc.subject.keywordVirus capsidspa
dc.subject.keywordVirus entryspa
dc.subject.keywordVirus nucleocapsidspa
dc.subject.keywordVirus replicationspa
dc.subject.keywordEbola virusspa
dc.subject.keywordEbola virus diseasespa
dc.subject.keywordPost-ebola virus disease syndromespa
dc.titleEbola virus disease: An emerging and re-emerging viral threatspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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