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HLA class II polymorphism in Latin American patients with multiple sclerosis

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dc.creatorRojas, Olga-Lucíaspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorCruz-Tapias, Paolaspa
dc.creatorSánchez, Jorge Luisspa
dc.creatorSuárez-Escudero, Juan-Camilospa
dc.creatorPatarroyo, Manuel-Alfonsospa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:44Z
dc.date.available2020-05-26T00:01:44Z
dc.date.created2010spa
dc.description.abstractObjective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: A total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p and lt; 0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p and lt; 0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p and lt; 0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p = 0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p and lt; 0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence 221VHFFKNIVT229 was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503. Conclusion: The current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications. © 2009 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2009.11.001
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23400
dc.language.isoengspa
dc.relation.citationEndPage413
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage407
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 9
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.9, No.6 (2010); pp. 407-413spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77949917895&doi=10.1016%2fj.autrev.2009.11.001&partnerID=40&md5=1b61091f56af782a8350393170a2f2f4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHLA antigen class 2spa
dc.subject.keywordGeneticeng
dc.subject.keywordHLA DR antigenspa
dc.subject.keywordMyelin basic proteinspa
dc.subject.keywordAdultspa
dc.subject.keywordAllelespa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordCase control studyspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordDNA extractionspa
dc.subject.keywordDNA polymorphismspa
dc.subject.keywordFemalespa
dc.subject.keywordGene identificationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordOligonucleotide probespa
dc.subject.keywordReviewspa
dc.subject.keywordRiskspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenetic Association Studiesspa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordHistocompatibility Testingspa
dc.subject.keywordHLA-DQ Antigensspa
dc.subject.keywordHLA-DR Antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMultiple Sclerosisspa
dc.subject.keywordMyelin Basic Proteinsspa
dc.subject.keywordPeptide Fragmentsspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtein Bindingspa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordHLA antigensspa
dc.subject.keywordLatin Americaspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordMyelin basic proteinspa
dc.titleHLA class II polymorphism in Latin American patients with multiple sclerosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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