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Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)

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dc.creatorLópez, Carolina
dc.creatorSuárez, Carlos F.
dc.creatorCadavid, Luis
dc.creatorPatarroyo, Manuel E.
dc.creatorPatarroyo, Manuel A.
dc.creator.googleLópez, Carolinaspa
dc.creator.googleSuárez, Carlos F.spa
dc.creator.googleCadavid, Luis F.spa
dc.creator.googlePatarroyo, Manuel E.spa
dc.creator.googlePatarroyo, Manuel A.spa
dc.date.accessioned2018-11-19T15:46:28Z
dc.date.available2018-11-19T15:46:28Z
dc.date.created2014
dc.date.issued2014-03-12
dc.description.abstractNon-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal model must be characterised to assess whether the results obtained here can be extrapolated to humans. Class I and II major histocompatibility complex (MHC) proteins are amongst the most important molecules involved in response to pathogens; in spite of this, the techniques available for genotyping these molecules are usually expensive and/or time-consuming. Previous studies have reported MHC-DRB class II gene typing by microsatellite in Old World primates and humans, showing that such technique provides a fast, reliable and effective alternative to the commonly used ones. Based on this information, a microsatellite present in MHC-DRB intron 2 and its evolutionary patterns were identified in two Aotus species (A. vociferans and A. nancymaae ), as well as its potential for genotyping class II MHC-DRB in these primates. © 2014 López et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0096973
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18702
dc.language.isoengspa
dc.relation.citationIssueNo. 5
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 9/No. 5 (2014)spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096973&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationWard, J.M., Vallender, E.J., The resurgence and genetic implications of New World primates in biomedical research (2012) Trends Genet, 28, pp. 586-591spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectADN complementariospa
dc.subjectAntígeno Hla Drspa
dc.subjectAntígeno Hla Drb1spa
dc.subjectAntígeno Hla Drb3spa
dc.subjectAntígeno mayor de histocompatibilidad clase 1spa
dc.subjectAntígeno mayor de histocompatibilidad clase 2spa
dc.subjectHla antígeno clase 2spa
dc.subjectADN microsatélitespa
dc.subjectAlelosspa
dc.subjectCélula animalspa
dc.subjectAotus Vociferansspa
dc.subjectEstudio controladospa
dc.subjectSecuencia de ADNspa
dc.subjectExónspa
dc.subjectAnálisis genéticospa
dc.subjectGenotipospa
dc.subjectTécnica de genotipadospa
dc.subjectIntrónspa
dc.subjectMhc Drb Genspa
dc.subjectMhc Drb1 Genspa
dc.subjectMhc Drb3 Genspa
dc.subjectMarcador de microsatélitespa
dc.subjectEvolución Molecularspa
dc.subjectFilogenia molecularspa
dc.subjectÁrbol filogenéticospa
dc.subjectOrnitorrincospa
dc.subjectAlineación de secuenciaspa
dc.subjectRepetición corta en tándemspa
dc.subjectAótidosspa
dc.subjectRepeticiones de microsatélitesspa
dc.subject.keywordMicrosatellite Repeatseng
dc.subject.keywordHistocompatibility Antigens Class Iieng
dc.subject.keywordAotus Vociferanslat
dc.subject.keywordAotidaeeng
dc.subject.keywordShort Tandem Repeateng
dc.subject.keywordSequence Alignmenteng
dc.subject.keywordPlatyrrhinieng
dc.subject.keywordPhylogenetic Treeeng
dc.subject.keywordMolecular Phylogenyeng
dc.subject.keywordMolecular Evolutioneng
dc.subject.keywordMicrosatellite Markereng
dc.subject.keywordMhc Drb3 Geneeng
dc.subject.keywordMhc Drb1 Geneeng
dc.subject.keywordMhc Drb Geneeng
dc.subject.keywordIntroneng
dc.subject.keywordGenotyping Techniqueeng
dc.subject.keywordGenotypeeng
dc.subject.keywordGenetic Analysiseng
dc.subject.keywordExoneng
dc.subject.keywordDna Sequenceeng
dc.subject.keywordControlled Studyeng
dc.subject.keywordAotus Nancymaaeeng
dc.subject.keywordAnimal Celleng
dc.subject.keywordMicrosatellite Dnaeng
dc.subject.keywordAlleleeng
dc.subject.keywordHla Antigen Class 2eng
dc.subject.keywordMajor Histocompatibility Antigen Class 2eng
dc.subject.keywordHla Drb3 Antigeneng
dc.subject.keywordMajor Histocompatibility Antigen Class 1eng
dc.subject.keywordHla Drb1 Antigeneng
dc.subject.keywordHla Dr Antigeneng
dc.subject.keywordComplementary Dnaeng
dc.subject.lembMalariaspa
dc.subject.lembHistocompatibilidadspa
dc.subject.lembExperimentación con animalesspa
dc.subject.lembPrimatesspa
dc.titleCharacterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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