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Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants

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dc.creatorAna S. Gonzalez-Reichespa
dc.creatorHala Alshammaryspa
dc.creatorSarah Schaeferspa
dc.creatorGopi Patelspa
dc.creatorJose Polancospa
dc.creatorJuan Manuel Carreñospa
dc.creatorAngela A. Amoakospa
dc.creatorAria Rookerspa
dc.creatorChristian Cognignispa
dc.creatorDaniel Flodaspa
dc.creatorAdriana van de Guchtespa
dc.creatorZain Khalilspa
dc.creatorKeith Farrugiaspa
dc.creatorNima Assadspa
dc.creatorJian Zhangspa
dc.creatorBremy Alburquerquespa
dc.creatorPARIS/PSP study groupspa
dc.creatorLevy A. Sominskyspa
dc.creatorCharles Gleasonspa
dc.creatorKomal Srivastavaspa
dc.creatorRobert Sebraspa
dc.creatorJuan David Ramirezspa
dc.creatorRadhika Banuspa
dc.creatorParas Shresthaspa
dc.creatorFlorian Krammerspa
dc.creatorAlberto Paniz-Mondolfispa
dc.creatorEmilia Mia Sordillospa
dc.creatorViviana Simonspa
dc.creatorHarm van Bakelspa
dc.date.accessioned2024-01-31T18:34:19Z
dc.date.available2024-01-31T18:34:19Z
dc.date.created2023-12-01spa
dc.date.issued2023spa
dc.descriptionPersistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported in immune-compromised individuals and people undergoing immune-modulatory treatments. Although intrahost evolution has been documented, direct evidence of subsequent transmission and continued stepwise adaptation is lacking. Here we describe sequential persistent SARS-CoV-2 infections in three individuals that led to the emergence, forward transmission, and continued evolution of a new Omicron sublineage, BA.1.23, over an eight-month period. The initially transmitted BA.1.23 variant encoded seven additional amino acid substitutions within the spike protein (E96D, R346T, L455W, K458M, A484V, H681R, A688V), and displayed substantial resistance to neutralization by sera from boosted and/or Omicron BA.1-infected study participants. Subsequent continued BA.1.23 replication resulted in additional substitutions in the spike protein (S254F, N448S, F456L, M458K, F981L, S982L) as well as in five other virus proteins. Our findings demonstrate not only that the Omicron BA.1 lineage can diverge further from its already exceptionally mutated genome but also that patients with persistent infections can transmit these viral variants. Thus, there is, an urgent need to implement strategies to prevent prolonged SARS-CoV-2 replication and to limit the spread of newly emerging, neutralization-resistant variants in vulnerable patients.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttp://doi.org/10.1038/s41467-023-38867-xspa
dc.identifier.issn2041-1723spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/42164
dc.language.isoengspa
dc.publisherUniversidad del Rosariospa
dc.relation.urihttps://www.nature.com/articles/s41467-023-38867-x.pdfspa
dc.rightsAttribution 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.sourceNature Communicationsspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectEvolutionspa
dc.subjectInfectionspa
dc.subjectSARS-CoV-2spa
dc.titleSequential intrahost evolution and onward transmission of SARS-CoV-2 variantsspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
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