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IgM predominance in autoimmune disease: Genetics and gender

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dc.creatorDuarte-Rey, Carolina
dc.creatorBogdanos, Dimitrios P.spa
dc.creatorLeung, Patrick S.C.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorGershwin, M. Ericspa
dc.date.accessioned2020-05-26T00:00:12Z
dc.date.available2020-05-26T00:00:12Z
dc.date.created2012spa
dc.description.abstractThe role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2011.12.001
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23177
dc.language.isoengspa
dc.relation.citationEndPageA412
dc.relation.citationIssueNo. 44018
dc.relation.citationStartPageA404
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 11
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.11, No.44018 (2012); pp. A404-A412spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84858438893&doi=10.1016%2fj.autrev.2011.12.001&partnerID=40&md5=87528f5b35066e35e5ea2292927c83e0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordActivation induced cytidine deaminasespa
dc.subject.keywordxxxeng
dc.subject.keywordAlpha interferonspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordAntivirus agentspa
dc.subject.keywordCd40 antigenspa
dc.subject.keywordCd40 ligandspa
dc.subject.keywordComplement component c3bspa
dc.subject.keywordI kappa b kinase gammaspa
dc.subject.keywordImmunoglobulinspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordRituximabspa
dc.subject.keywordSmooth muscle antibodyspa
dc.subject.keywordThyroid hormonespa
dc.subject.keywordAntiviral therapyspa
dc.subject.keywordArthritisspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hemolytic anemiaspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordAutoimmune thrombocytopeniaspa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordB lymphocytespa
dc.subject.keywordCd4+ t lymphocytespa
dc.subject.keywordCell selectionspa
dc.subject.keywordChronic diarrheaspa
dc.subject.keywordCoombs positive hemolytic anemiaspa
dc.subject.keywordCryoglobulinemiaspa
dc.subject.keywordDiscoid lupus erythematosusspa
dc.subject.keywordEnteritisspa
dc.subject.keywordGenderspa
dc.subject.keywordGene expressionspa
dc.subject.keywordGene mutationspa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHepatitis cspa
dc.subject.keywordHormone substitutionspa
dc.subject.keywordHumanspa
dc.subject.keywordHyper igm syndromespa
dc.subject.keywordHypothyroidismspa
dc.subject.keywordImmunoglobulin m deficiencyspa
dc.subject.keywordInfectionspa
dc.subject.keywordInterstitial pneumoniaspa
dc.subject.keywordKaryotype 47eng
dc.subject.keywordLiver injuryspa
dc.subject.keywordLymphoproliferative diseasespa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordNephritisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmapheresisspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordStem cell transplantationspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordX chromosomespa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordB-lymphocytesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordHyper-igm immunodeficiency syndromespa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordMalespa
dc.subject.keywordSex factorsspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hemolytic anemiaspa
dc.subject.keywordCryoglobulinemiaspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.titleIgM predominance in autoimmune disease: Genetics and genderspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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