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Parasite-related genetic and epigenetic aspects and host factors influencing plasmodium falciparum invasion of erythrocytes

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dc.creatorArarat-Sarria, Monicaspa
dc.creatorPatarroyo, Manuel A.spa
dc.creatorCurtidor, Hernando
dc.date.accessioned2020-05-26T00:08:23Z
dc.date.available2020-05-26T00:08:23Z
dc.date.created2019spa
dc.description.abstractMalaria, a disease caused by Plasmodium parasites, is widespread throughout tropical and sub-tropical regions worldwide; it mostly affects children and pregnant woman. Eradication has stalled despite effective prevention measures and medication being available for this disease; this has mainly been due to the parasite's resistance to medical treatment and the mosquito vector's resistance to insecticides. Tackling such resistance involves using renewed approaches and techniques for accruing a deep understanding of the parasite's biology, and developing new drugs and vaccines. Studying the parasite's invasion of erythrocytes should shed light on its ability to switch between invasion phenotypes related to the expression of gene sets encoding proteins acting as ligands during target cell invasion, thereby conferring mechanisms for evading a particular host's immune response and adapting to changes in target cell surface receptors. This review considers some factors influencing the expression of such phenotypes, such as Plasmodium's genetic, transcriptional and epigenetic characteristics, and explores some host-related aspects which could affect parasite phenotypes, aiming at integrating knowledge regarding this topic and the possible relationship between the parasite's biology and host factors playing a role in erythrocyte invasion. © 2019 Ararat-Sarria, Patarroyo and Curtidor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fcimb.2018.00454
dc.identifier.issn22352988
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24081
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationIssueNo. JAN
dc.relation.citationTitleFrontiers in Cellular and Infection Microbiology
dc.relation.citationVolumeVol. 9
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology, ISSN:22352988, Vol.9, No.JAN (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060604661&doi=10.3389%2ffcimb.2018.00454&partnerID=40&md5=242191120f7a2bf35e0d7fec95c2972dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordTranscription factorspa
dc.subject.keywordCell invasionspa
dc.subject.keywordChromatin immunoprecipitationspa
dc.subject.keywordCrispr-cas9 systemspa
dc.subject.keywordEpigeneticsspa
dc.subject.keywordErythrocytespa
dc.subject.keywordGene expressionspa
dc.subject.keywordGene mutationspa
dc.subject.keywordGene structurespa
dc.subject.keywordImmune responsespa
dc.subject.keywordMalariaspa
dc.subject.keywordMutational analysisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOpen reading framespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtozoal geneticsspa
dc.subject.keywordReviewspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordEndocytosisspa
dc.subject.keywordErythrocytespa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordEndocytosisspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordHost-pathogen interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordInvasion factorsspa
dc.subject.keywordMalariaspa
dc.subject.keywordPhenotype changespa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordRegulatory mechanismspa
dc.titleParasite-related genetic and epigenetic aspects and host factors influencing plasmodium falciparum invasion of erythrocytesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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