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Metabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistance

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dc.creatorÁlvarez C.spa
dc.creatorRamírez-Campillo R.spa
dc.creatorRamírez-Vélez R.spa
dc.creatorMartínez C.spa
dc.creatorCastro-Sepúlveda M.spa
dc.creatorAlonso-Martínez A.spa
dc.creatorIzquierdo M.spa
dc.date.accessioned2020-05-25T23:55:36Z
dc.date.available2020-05-25T23:55:36Z
dc.date.created2018spa
dc.description.abstractBackground:Little evidence exists on which variables of body composition or muscular strength mediates more glucose control improvements taking into account inter-individual metabolic variability to different modes of exercise training.Objective:We examined â mediators' to the effects of 6-weeks of resistance training (RT) or high-intensity interval training (HIT) on glucose control parameters in physically inactive schoolchildren with insulin resistance (IR). Second, we also determined both training-induce changes and the prevalence of responders (R) and non-responders (NR) to decrease the IR level.Methods:Fifty-six physically inactive children diagnosed with IR followed a RT or supervised HIT program for 6 weeks. Participants were classified based on 'HOMA-IR into glycemic control R (decrease in homeostasis model assessment-IR (HOMA-IR) less than 3.0 after intervention) and NRs (no changes or values HOMA-IR?43.0 after intervention). The primary outcome was HOMA-IR associated with their mediators; second, the training-induced changes to glucose control parameters; and third the report of R and NR to improve body composition, cardiovascular, metabolic and performance variables.Results:Mediation analysis revealed that improvements (decreases) in abdominal fat by the waist circumference can explain more the effects (decreases) of HOMA-IR in physically inactive schoolchildren under RT or HIT regimes. The same analysis showed that increased one-maximum repetition leg-extension was correlated with the change in HOMA-IR (?=0.058; P=0.049). Furthermore, a change in the waist circumference fully mediated the dose-response relationship between changes in the leg-extension strength and HOMA-IR (??=0.004; P=0.178). RT or HIT were associated with significant improvements in body composition, muscular strength, blood pressure and cardiometabolic parameters irrespective of improvement in glycemic control response. Both glucose control RT-R and HIT-R (respectively), had significant improvements in mean HOMA-IR, mean muscular strength leg-extension and mean measures of adiposity.Conclusions:The improvements in the lower body strength and the decreases in waist circumference can explain more the effects of the improvements in glucose control of IR schoolchildren in R group after 6 weeks of RT or HIT, showing both regimes similar effects on body composition or muscular strength independent of interindividual metabolic response variability. © 2018 Macmillan Publishers Limited, part of Springer Nature.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/ijo.2017.177
dc.identifier.issn03070565
dc.identifier.issn14765497
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22139
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationEndPage87
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage79
dc.relation.citationTitleInternational Journal of Obesity
dc.relation.citationVolumeVol. 42
dc.relation.ispartofInternational Journal of Obesity, ISSN:03070565, 14765497, Vol.42, No.1 (2018); pp. 79-87spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041192795&doi=10.1038%2fijo.2017.177&partnerID=40&md5=dfb4532515ca31474c6df04fd4a324d7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGlucosespa
dc.subject.keywordInsulinspa
dc.subject.keywordAbdominal fatspa
dc.subject.keywordArticlespa
dc.subject.keywordBody compositionspa
dc.subject.keywordCardiovascular performancespa
dc.subject.keywordChildspa
dc.subject.keywordControlled clinical trialspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGeneral condition improvementspa
dc.subject.keywordGlucose blood levelspa
dc.subject.keywordGlucose homeostasisspa
dc.subject.keywordGlycemic controlspa
dc.subject.keywordHigh intensity interval trainingspa
dc.subject.keywordHomeostasis model assessmentspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin blood levelspa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPhysical inactivityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordResistance trainingspa
dc.subject.keywordSchool childspa
dc.subject.keywordSedentary lifestylespa
dc.subject.keywordWaist circumferencespa
dc.subject.keywordAnalysisspa
dc.subject.keywordExercisespa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordMetabolismspa
dc.subject.keywordMuscle strengthspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordStatistics and numerical dataspa
dc.subject.keywordBlood glucosespa
dc.subject.keywordChildspa
dc.subject.keywordExercisespa
dc.subject.keywordFemalespa
dc.subject.keywordHigh-intensity interval trainingspa
dc.subject.keywordHumansspa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordMalespa
dc.subject.keywordMuscle strengthspa
dc.subject.keywordResistance trainingspa
dc.titleMetabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistancespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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