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Evidencia sobre la expresión de Her-2 en la enfermedad de Paget Extramamaria

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dc.contributor.advisorRubiano Forero, Wilson
dc.contributor.advisorDe la Peña, Jairo
dc.contributor.advisorRamírez Clavijo, Sandra Rocío
dc.contributor.advisorAguilera Otalvaro, Paula Andrea
dc.contributor.advisorVillaveces, Mariana
dc.creatorMonroy Muñoz, Ricardo
dc.creator.degreeEspecialista en Mastología
dc.date.accessioned2018-07-30T14:42:46Z
dc.date.available2018-07-30T14:42:46Z
dc.date.created2018-07-11
dc.date.issued2018
dc.descriptionIntroducción: La enfermedad de Paget extramamaria EPEM es una entidad poco común de la piel, con un cuadro clínico insidioso pero agresivo por su gran compromiso loco regional y potencial para producir metástasis e incluso la muerte. El HER2 es un biomarcador de interés por sus implicaciones clínicas en el diagnóstico, evolución y pronóstico de la enfermedad. El presente estudio propone conocer la evidencia relacionada con el comportamiento de este biomarcador en la enfermedad de Paget extramamaria. Metodología: Revisión sistemática de literatura con un componente meta-analítico en el cual se extrajo la evidencia sobre el comportamiento del HER2 en pacientes con EPEM, siguiendo el contenido de diferentes artículos publicados en las principales base de datos (Medline, Embase, Cochrane, Pubmed, Google Schoolar, Science Direct, tripdatabase) sin límite de tiempo en las publicaciones. Resultados: De 147 artículos encontrados sobre el tema, 38 cumplieron criterios para su inclusión, 692 pacientes en total, 51.1% de género masculino. La proteína HER2 se sobreexpresó en el 42.77% de los casos de EPEM extramamaria y la amplificación del gen ERBB2 fue positiva en el 11.1% de los casos. La invasión dérmica se presentó en el 87.2% de los casos mientras que la metástasis regional y recurrencia posterior a tratamiento se presentó en un 76.8% y 93.9% respectivamente. La asociación entre Her-2 y la EPEM fue significativa (p <0.001). Discusión: Existe sobrexpresión y/o amplificación del HER2 en la EPEM con un porcentaje de positividad objetivo de 42%, por tanto, la terapia con terapias blanco anti-HER2 debe considerarse como una novedosa estrategia terapéutica en casos seleccionados con positividad para este marcador.spa
dc.description.abstractBackround: Paget's disease extramammary EPEM is an uncommon entity of the skin, with an insidious but aggressive clinical manifestations due to its great locoregional commitment and potential to produce metastasis and even death. HER2 is a biomarker that is currently under study due to its clinical implications in the diagnosis, evolution and prognosis of the disease. The present study proposes to identify the evidence related to the behavior of this biomarker in extramammary Paget's disease. Methods: A systematic review of literature with a meta-analytical component was performed in which the evidence of the behavior of HER2 in patients with EPEM was extracted, according to different articles published in the main database (Medline, Embase, Cochrane, Pubmed, Google Schoolar, Science Direct, tripdatabase) without time limit for the publications. Results: Of 147 articles found on the subject, 38 met criteria for inclusion, (692 patients in total, 51.1% male). HER2 protein was over-expressed in 42.77% of the cases and the amplification of the ERBB2 gene was positive in 11.1%. The dermal invasion occurred in 87.2% of the cases, while the regional metastasis and recurrence after treatment occurred in 76.8% and 93.9% respectively. The association between Her-2 expressoin and the EPEM was significat (p<0.01). Discussion: There is overexpression and/or amplification of HER-2 in EPEM with a target positivity percentage of 42%, therefore therapy with anti-HER2 target therapies should be considered as a possible new therapeutic strategy in selected cases with positivity for this marker.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.48713/10336_18230
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18230
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización de Mastologíaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectEnfermedad Paget extramamariaspa
dc.subjectHER2spa
dc.subjectSobreexpresiónspa
dc.subjectAmplificaciónspa
dc.subject.ddcGinecología & otras especialidades médicas
dc.subject.keywordPaget extramammary diseaseeng
dc.subject.keywordHER2eng
dc.subject.keywordOverexpressioneng
dc.subject.keywordAmplificationeng
dc.subject.lembEnfermedad de Paget Extramamariaspa
dc.subject.lembEnfermedades de la mamaspa
dc.titleEvidencia sobre la expresión de Her-2 en la enfermedad de Paget Extramamariaspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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