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Prevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosis

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dc.creatorShor D.B.-A.spa
dc.creatorWeiss G.A.spa
dc.creatorBarzilai O.spa
dc.creatorRam M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorShoenfeld Y.spa
dc.creatorSherer Y.spa
dc.date.accessioned2020-05-25T23:55:44Z
dc.date.available2020-05-25T23:55:44Z
dc.date.created2015spa
dc.description.abstractBackground: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- ?2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain. © 2015, Israel Medical Association. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn15651088
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22196
dc.language.isoengspa
dc.publisherIsrael Medical Associationspa
dc.relation.citationEndPage562
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage559
dc.relation.citationTitleIsrael Medical Association Journal
dc.relation.citationVolumeVol. 17
dc.relation.ispartofIsrael Medical Association Journal, ISSN:15651088, Vol.17, No.9 (2015); pp. 559-562spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84943655947&partnerID=40&md5=447de3270c9e2afafa340f94a019e1faspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBeta2 glycoprotein 1spa
dc.subject.keywordCardiolipin antibodyspa
dc.subject.keywordantiphospholipideng
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordPhosphatidylethanolaminespa
dc.subject.keywordPhosphatidylserinespa
dc.subject.keywordPhospholipid antibodyspa
dc.subject.keywordProthrombinspa
dc.subject.keywordProthrombin complexspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordPhospholipid antibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordFemalespa
dc.subject.keywordFlow cytometryspa
dc.subject.keywordFluorescence analysisspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunoassayspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordBloodspa
dc.subject.keywordCase control studyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordAdultspa
dc.subject.keywordAntibodieseng
dc.subject.keywordCase-control studiesspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin mspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordAntiphospholipid syndrome (aps)spa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBeta 2-glycoprotein 1 (?2gpi)spa
dc.subject.keywordCardiolipinspa
dc.subject.keywordImmunoglobulin (ig)spa
dc.subject.keywordMultiple sclerosis (ms)spa
dc.titlePrevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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