Ítem
Solo Metadatos

Identifying Plasmodium falciparum merozoite surface antigen 3 (MSP3) protein peptides that bind specifically to erythrocytes and inhibit merozoite invasion

Mostrar el registro sencillo de la publicación
dc.creatorRodríguez, Luis E.spa
dc.creatorCurtidor, Hernandospa
dc.creatorOcampo, Marisol
dc.creatorGarcia, Javierspa
dc.creatorPuentes, Alvarospa
dc.creatorValbuena, Johnspa
dc.creatorVera, Ricardospa
dc.creatorLópez, Ramsesspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-19T14:44:11Z
dc.date.available2020-08-19T14:44:11Z
dc.date.created2005-07spa
dc.description.abstractReceptor–ligand interactions between synthetic peptides and normal human erythrocytes were studied to determine Plasmodium falciparum merozoite surface protein?3 (MSP?3) FC27 strain regions that specifically bind to membrane surface receptors on human erythrocytes. Three MSP?3 protein high activity binding peptides (HABPs) were identified; their binding to erythrocytes became saturable, had nanomolar affinity constants, and became sensitive on being treated with neuraminidase and trypsin but were resistant to chymotrypsin treatment. All of them specifically recognized 45?, 55?, and 72?kDa erythrocyte membrane proteins. They all presented ??helix structural elements. All HABPs inhibited in vitro P. falciparum merozoite invasion of erythrocytes by ?55%–85%, suggesting that MSP?3 protein's role in the invasion process probably functions by using mechanisms similar to those described for other MSP family antigens.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1110/ps.041304505
dc.identifier.issnISSN: 0961-8368
dc.identifier.issnEISSN: 1469-896X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27841
dc.language.isoengspa
dc.publisherThe Protein Societyspa
dc.publisherJohn Wiley & Sonspa
dc.relation.citationEndPage1786
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1778
dc.relation.citationTitleProtein Science
dc.relation.citationVolumeVol. 14
dc.relation.ispartofProtein Science, ISSN: 0961-8368;EISSN: 1469-896X, Vol.14, No.7 (July 2005); pp. 1778-1786spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1110/ps.041304505spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceProtein Sciencespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordP. falciparumspa
dc.subject.keywordMerozoite surface protein 3spa
dc.subject.keywordErythrocytespa
dc.subject.keywordInvasion inhibitionspa
dc.titleIdentifying Plasmodium falciparum merozoite surface antigen 3 (MSP3) protein peptides that bind specifically to erythrocytes and inhibit merozoite invasionspa
dc.title.TranslatedTitleIdentificación de péptidos de la proteína del antígeno de superficie 3 del merozoito de Plasmodium falciparum (MSP3) que se unen específicamente a los eritrocitos e inhiben la invasión de merozoitosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos