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Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6

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dc.creatorRojas M.spa
dc.creatorRodríguez Velandia, Yhojan Alexisspa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Y.spa
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRodríguez Jiménez, Mónica María del Pilarspa
dc.creatorMolano González, Nicolásspa
dc.creatorMantilla R.D.spa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:17Z
dc.date.available2020-05-26T00:04:17Z
dc.date.created2019spa
dc.description.abstractOBJECTIVES: Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc. METHODS: Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data. RESULTS: Interleukin-6 (IL-6) levels were associated with severity of symptoms (?=1.8395, p=0.04), and low resilience scores (?= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity. CONCLUSIONS: The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0392856X
dc.identifier.issn1593098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23673
dc.language.isoengspa
dc.publisherNLM (Medline)spa
dc.relation.citationEndPage22
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage15
dc.relation.citationTitleClinical and experimental rheumatology
dc.relation.citationVolumeVol. 37
dc.relation.ispartofClinical and experimental rheumatology, ISSN:0392856X, 1593098X, Vol.37, No.4 (2019); pp. 15-22spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059307721&partnerID=40&md5=673e372e2784facc899a1e6227bb6402spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordsystemiceng
dc.subject.keywordCytokinespa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordBloodspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordCytokinesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInterleukin-6spa
dc.subject.keywordSclerodermaeng
dc.subject.keywordSeverity of illness indexspa
dc.titleCytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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