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Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study

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dc.creatorPompeu, Fernandospa
dc.creatorCala, Mónica P.spa
dc.creatorRamos Caballero, Diana Marcelaspa
dc.creatorMonnerat, Gustavospa
dc.creatorCristancho, Edgarspa
dc.creatorSantos, Caleb G. M.spa
dc.creatorD’Alessandro, Angelospa
dc.creatorPaulucio, Dailsonspa
dc.creatorLeón, Lizethspa
dc.creatorSánchez, Carlos A. R.spa
dc.creatorMancera-Soto, Ericaspa
dc.creatorPardo-Rodriguez, Danielspa
dc.date.accessioned2025-07-21T16:49:15Z
dc.date.available2025-07-21T16:49:15Z
dc.date.created2025-05-09spa
dc.date.issued2025-05-09spa
dc.description.abstractAthletes use hypoxic training methods to enhance their performance under altitude conditions. Comparative studies involving populations from low (500–2,000 m) and moderate (2,000–3,000 m) altitudes offer an opportunity to understand the mechanisms behind adaptations to hypoxia. The present study combined data from metabolomics analysis based on gas- and liquidchromatography mass spectrometry (GC-MS and LC-MS) to compare plasma profiles from 80 adolescent athletes at moderate- or low altitudes. 161 metabolites were identified, including 84 elevated and 77 decreased in moderate-altitude adolescents compared to their low-altitude counterparts. Pathway analysis revealed that metabolites related to carbohydrates, amino acids, and lipid metabolism differed between groups. Lipid metabolism was significantly altered in moderate-altitude athletes, including pathways such as linolenic and linoleic acid, sphingolipid, and arachidonic acid, as well as processes involving the transfer of acetyl groups into mitochondria and fatty acid biosynthesis. Biomarker analysis looking for signatures of chronic adaptation to moderate altitude identified glycerol and 5-oxoproline metabolites amongst the variables with the strongest sensitivity and specificity. This study demonstrates differences in metabolic profiles between moderate- and lowaltitude populations and highlights the potential of these differential metabolites and associated metabolic pathways to provide new insights into the mechanisms of adaptation to moderate altitude.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.3389/fmolb.2025.1571103spa
dc.identifier.issn2296-889Xspa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46087
dc.language.isoengspa
dc.publisherFrontiersspa
dc.relation.ispartofFrontiers in Molecular Biosciences, Sec. Metabolomics Volume 12 (2025)spa
dc.relation.urihttps://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1571103/fullspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceFrontiers in Molecular Biosciencesspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordUntargeted metabolomicseng
dc.subject.keywordAltitude trainingeng
dc.subject.keywordHypoxiaeng
dc.subject.keywordEndurance exerciseeng
dc.subject.keywordAdolescenteng
dc.titleMetabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional studyspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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