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Clonal dispersal of Cryptococcus gattii VGII in an endemic region of cryptococcosis in Colombia

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dc.creatorFiracative Ropero, Sandra Carolinaspa
dc.creatorTorres, Germánspa
dc.creatorMeyer, Wielandspa
dc.creatorEscandón, Patriciaspa
dc.date.accessioned2020-05-25T23:56:10Z
dc.date.available2020-05-25T23:56:10Z
dc.date.created2019spa
dc.description.abstractThis study characterized the genotype and phenotype of Cryptococcus gattii VGII isolates from Cucuta, an endemic region of cryptococcal disease in Colombia, and compared these traits with those from representative isolates from the Vancouver Island outbreak (VGIIa and VGIIb). Genetic diversity was assessed by multilocus sequence typing (MLST) analysis. Phenotypic characteristics, including growth capacity under different temperature and humidity conditions, macroscopic and microscopic morphology, phenotypic switching, mating type, and activity of extracellular enzymes were studied. Virulence was studied in vivo in a mouse model. MLST analysis showed that the isolates from Cucuta were highly clonal, with ST25 being the most common genotype. Phenotypically, isolates from Cucuta showed large cell and capsular sizes, and shared phenotypic traits and enzymatic activities among them. The mating type a prevailed among the isolates, which were fertile and of considerable virulence in the animal model. This study highlights the need for a continuous surveillance of C. gattii in Colombia, especially in endemic areas like Cucuta, where the highest number of cryptococcosis cases due to this species is reported. This will allow the early detection of potentially highly virulent strains that spread clonally, and can help prevent the occurrence of outbreaks in Colombia and elsewhere. © 2019 by the authors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/jof5020032
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22348
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 2
dc.relation.citationTitleJournal of Fungi
dc.relation.citationVolumeVol. 5
dc.relation.ispartofJournal of Fungi, Vol.5, No.2 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068416272&doi=10.3390%2fjof5020032&partnerID=40&md5=dc3ecf1eaaea9971be1636f9d38a0d2dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCryptococcus gattiispa
dc.subject.keywordGenotypespa
dc.subject.keywordMLSTspa
dc.subject.keywordPhenotypespa
dc.subject.keywordVirulence factorsspa
dc.titleClonal dispersal of Cryptococcus gattii VGII in an endemic region of cryptococcosis in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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