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The autoimmune ecology: An update

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorRestrepo-Jiménez P.spa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.date.accessioned2020-05-26T00:05:46Z
dc.date.available2020-05-26T00:05:46Z
dc.date.created2018spa
dc.description.abstractPurpose of review The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, Vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics. Recent findings Smoking is associated with an increased risk for most of the autoimmune diseases. Carbamylation of proteins as well as NETosis have emerged as possible new pathophysiological mechanisms for rheumatoid arthritis. Low-to-moderate alcohol consumption seems to decrease the risk of systemic lupus erythematosus and rheumatoid arthritis, and studies of vitamin have suggested a beneficial effect on these conditions. Coffee intake appears to be a risk factor for type 1 diabetes mellitus and rheumatoid arthritis and a protective factor for multiple sclerosis and primary biliary cholangitis. Summary Recent studies support the previously established positive associations between environmental factors and most of the autoimmune diseases. Nevertheless, further studies from the perspective of metabolomics, proteomics and genomics will help to clarify the effect of environment on autoimmune diseases. © Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/BOR.0000000000000498
dc.identifier.issn15316963
dc.identifier.issn10408711
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23824
dc.language.isoengspa
dc.publisherLippincott Williams and Wilkinsspa
dc.relation.citationEndPage360
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage350
dc.relation.citationTitleCurrent Opinion in Rheumatology
dc.relation.citationVolumeVol. 30
dc.relation.ispartofCurrent Opinion in Rheumatology, ISSN:15316963, 10408711, Vol.30, No.4 (2018); pp. 350-360spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85048270895&doi=10.1097%2fBOR.0000000000000498&partnerID=40&md5=dffe20cd0a63981f87834cd50bbe94a7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlcoholspa
dc.subject.keywordVitamin dspa
dc.subject.keywordAlcohol consumptionspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCigarette smokingspa
dc.subject.keywordCoffeespa
dc.subject.keywordEcologyspa
dc.subject.keywordHumanspa
dc.subject.keywordMetabolomicsspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMetabolismspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSmokingspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordHumansspa
dc.subject.keywordMetabolomicsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSmokingspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmune ecologyspa
dc.subject.keywordExposomespa
dc.subject.keywordMetabolomicsspa
dc.subject.keywordReviewspa
dc.titleThe autoimmune ecology: An updatespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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