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Molecular epidemiology and characterization of virulence genes of community-acquired and hospital-acquired methicillin-resistant staphylococcus aureus isolates in Colombia

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dc.creatorChavarro Portillo, Bibianaspa
dc.creatorMoreno, Jaime Enriquespa
dc.creatorYomayusa, Nancyspa
dc.creatorAlvarez, Carlos Arturospa
dc.creatorCastro Cardozo, Betsy Esperanzaspa
dc.creatorEscobar Pérez, Javier Antoniospa
dc.creatorDíaz, Paula Luciaspa
dc.creatorIbáñez Pinilla, Milcíadesspa
dc.creatorMendez-Alvarez, Sebastiánspa
dc.creatorLeal, Aura Luciaspa
dc.creatorVanegas Gómez, Natashaspa
dc.date.accessioned2020-08-06T16:20:29Z
dc.date.available2020-08-06T16:20:29Z
dc.date.created2013spa
dc.description.abstractObjective: To determine the molecular epidemiology and presence of virulence genes in communityacquired (CA) and hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) isolates and their relationship to clinical outcomes. Methods: An observational and prospective study of infections caused by MRSA was conducted between June 2006 and December 2007 across seven hospitals in three Colombian cities. MRSA isolates were analyzed for SCCmec. Also, pulsed-field gel electrophoresis and multilocus sequence typing were performed and 25 virulence genes were identified. Results: Two hundred and seventy isolates were collected from 262 adult hospital patients with MRSA infections. Overall, 68% of the isolates were classified as HA-MRSA and 32% as CA-MRSA. We identified differences in the patterns of virulence genes: 85% of HA-MRSA isolates possessed the enterotoxin gene cluster (egc), whereas 92% of CA-MRSA isolates possessed the lukF-PV/lukS-PV genes. Multivariate analysis showed an increased risk of mortality for seg (p = 0.001, odds ratio 4.73) and a protective effect for eta (p = 0.018, odds ratio 0.33). Conclusions: Our study confirms that three clones of MRSA predominantly circulate in Colombia: a Chilean clone, a pediatric clone that causes HA-MRSA infections, and a USA300-related clone (SCCmec IVc) in CA-MRSA infections, which differ in the content of clinically important virulence genes. This study confirms that PVL is not a determinant of severity or mortality in CA-MRSA infections. 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2013.02.029
dc.identifier.issnISSN: 1201-9712
dc.identifier.issnEISSN: 1878-3511
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26027
dc.language.isoengspa
dc.publisherInternational Society for Infectious Diseasesspa
dc.publisherElsevierspa
dc.relation.citationEndPagee749
dc.relation.citationIssueNo. 9
dc.relation.citationStartPagee744
dc.relation.citationTitleInternational Journal of Infectious Diseases
dc.relation.citationVolumeVol. 17
dc.relation.ispartofInternational Journal of Infectious Diseases, ISSN: 1201-9712;EISSN: 1878-3511, Vol.17, No.9 (September, 2013); pp.e744-e749spa
dc.relation.urihttps://www.ijidonline.com/action/showPdf?pii=S1201-9712%2813%2900122-7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceInternational Journal of Infectious Diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordStaphylococcus aureusspa
dc.subject.keywordCA-MRSAspa
dc.subject.keywordAntibiotic resistancespa
dc.subject.keywordEnterotoxinsspa
dc.subject.keywordUSA300spa
dc.titleMolecular epidemiology and characterization of virulence genes of community-acquired and hospital-acquired methicillin-resistant staphylococcus aureus isolates in Colombiaspa
dc.title.TranslatedTitleEpidemiología molecular y caracterización de genes de virulencia de aislados de estafilococo aureus resistentes a la meticilina adquiridos en la comunidad y adquiridos en el hospital en Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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