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Experimental models of glaucoma: A powerful translational tool for the future development of new therapies for glaucoma in humans—A review of the literature

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dc.creatorEvangelho, Karinespa
dc.creatorMastronardi, Claudio A.spa
dc.creatorde-la-Torre, Alejandraspa
dc.date.accessioned2020-05-25T23:56:58Z
dc.date.available2020-05-25T23:56:58Z
dc.date.created2019spa
dc.description.abstractGlaucoma is a common complex disease that leads to irreversible blindness worldwide. Even though preclinical studies showed that lowering intraocular pressure (IOP) could prevent retinal ganglion cells loss, clinical evidence suggests that lessening IOP does not prevent glaucoma progression in all patients. Glaucoma is also becoming more prevalent in the elderly population, showing that age is a recognized major risk factor. Indeed, recent findings suggest that age-related tissue alterations contribute to the development of glaucoma and have encouraged exploration for new treatment approaches. In this review, we provide information on the most frequently used experimental models of glaucoma and describe their advantages and limitations. Additionally, we describe diverse animal models of glaucoma that can be potentially used in translational medicine and aid an efficient shift to the clinic. Experimental animal models have helped to understand the mechanisms of formation and evacuation of aqueous humor, and the maintenance of homeostasis of intra-ocular pressure. However, the transfer of pre-clinical results obtained from animal studies into clinical trials may be difficult since the type of study does not only depend on the type of therapy to be performed, but also on a series of factors observed both in the experimental period and the period of transfer to clinical application. Conclusions: Knowing the exact characteristics of each glaucoma experimental model could help to diminish inconveniences related to the process of the translation of results into clinical application in humans. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/medicina55060280
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22573
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 6
dc.relation.citationTitleMedicina (Lithuania)
dc.relation.citationVolumeVol. 55
dc.relation.ispartofMedicina (Lithuania), Vol.55, No.6 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068485949&doi=10.3390%2fmedicina55060280&partnerID=40&md5=1e4d40114775ac2123ef4540d00bce8espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAgespa
dc.subject.keywordbiologicaleng
dc.subject.keywordanimaleng
dc.subject.keywordAnimalspa
dc.subject.keywordBiological modelspa
dc.subject.keywordDisease modelspa
dc.subject.keywordDrug effectspa
dc.subject.keywordGlaucomaspa
dc.subject.keywordHumanspa
dc.subject.keywordIntraocular pressurespa
dc.subject.keywordLeporidaespa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordRodentspa
dc.subject.keywordAge factorsspa
dc.subject.keywordAnimalsspa
dc.subject.keywordDisease modelseng
dc.subject.keywordGlaucomaspa
dc.subject.keywordHumansspa
dc.subject.keywordIntraocular pressurespa
dc.subject.keywordModelseng
dc.subject.keywordRabbitsspa
dc.subject.keywordRodentiaspa
dc.subject.keywordAgingspa
dc.subject.keywordAnimalsspa
dc.subject.keywordExperimental modelsspa
dc.subject.keywordGlaucomaspa
dc.subject.keywordTherapyspa
dc.subject.keywordTranslational ophthalmologyspa
dc.titleExperimental models of glaucoma: A powerful translational tool for the future development of new therapies for glaucoma in humans—A review of the literaturespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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