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Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus

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dc.creatorFranco, Juan-Sebastianspa
dc.creatorAmaya-Amaya, Jennyspa
dc.creatorMolano González, Nicolás
dc.creatorCaro-Moreno, Julianspa
dc.creatorRodríguez Jiménez, Mónica María del Pilar
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorMantilla, Rubén Dspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:21Z
dc.date.available2020-05-26T00:04:21Z
dc.date.created2015spa
dc.description.abstractObjectives To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. Methods A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR). Results In our cohort, the prevalence of confirmed AH was 12%. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95% CI 1·98-28·54, P = 0·004), Sjögren's Syndrome (SS) (AOR 23·2, 95% CI 1·89-359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti-CCP) (AOR 10·35, 95% CI 1·04-121·26, P = 0·047) were associated with AH-SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH-SLE. In the SLR, the prevalence of AITD ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement. Conclusions AITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke-free policies in patients with SLE. © 2014 John Wiley and Sons Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/cen.12662
dc.identifier.issn13652265
dc.identifier.issn03000664
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23679
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage950
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage943
dc.relation.citationTitleClinical Endocrinology
dc.relation.citationVolumeVol. 83
dc.relation.ispartofClinical Endocrinology, ISSN:13652265, 03000664, Vol.83, No.6 (2015); pp. 943-950spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84920085462&doi=10.1111%2fcen.12662&partnerID=40&md5=97229f70143effedae7f1b86cddc70cespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntimalarial agentspa
dc.subject.keywordsystemiceng
dc.subject.keywordAutoantibodyspa
dc.subject.keywordautoimmuneeng
dc.subject.keywordautoimmuneeng
dc.subject.keywordAzathioprinespa
dc.subject.keywordCyclic citrullinated peptide antibodyspa
dc.subject.keywordCyclophosphamidespa
dc.subject.keywordLevothyroxinespa
dc.subject.keywordMycophenolate mofetilspa
dc.subject.keywordRituximabspa
dc.subject.keywordSteroidspa
dc.subject.keywordThyroglobulin antibodyspa
dc.subject.keywordThyroid peroxidasespa
dc.subject.keywordAdultspa
dc.subject.keywordAntibody blood levelspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hypothyroidismspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordColombianspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHypothyroidismspa
dc.subject.keywordImmunosuppressive treatmentspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOnset agespa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSmokingspa
dc.subject.keywordSmoking banspa
dc.subject.keywordSteroid therapyspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdolescentspa
dc.subject.keywordComplicationspa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHypothyroidismspa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordPathologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordThyroiditiseng
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordHypothyroidismspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordThyroiditiseng
dc.subject.keywordYoung adultspa
dc.titleAutoimmune thyroid disease in Colombian patients with systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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