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New treatment modalities for neovascular age-related macular degeneration

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dc.creatorSchlottmann, Patricio Gspa
dc.creatorAlezzandrini, Arturo Aspa
dc.creatorZas, Marcelospa
dc.creatorRodriguez, Francisco Jspa
dc.creatorLuna, José Dspa
dc.creatorWu, Lihtehspa
dc.date.accessioned2020-05-25T23:59:33Z
dc.date.available2020-05-25T23:59:33Z
dc.date.created2017spa
dc.description.abstractAge-related macular degeneration (AMD) is considered one of the main causes of severe vision loss in older adults. The neovascular form (nAMD) is an advanced stage, which is responsible for the most severe vision loss. Vascular endothelial growth factor (VEGF) is at present the main factor that leads to the development of a neovascular membrane and the increased leakage from the membrane to the retina. At present, anti-VEGF therapy is the only treatment that achieves vision gains in many patients and halts progression in most of them. VEGF blockade can be achieved with several molecules and various treatment regimens, which have been studied with excellent results. Unfortunately, real-world data has shown to be far less efficacious than clinical trials. This gap between clinical trials and real-world results is an unmet medical need that supports the necessity of new treatment modalities for nAMD. Of the various treatments being studied, anti-VEGFs of higher efficacy and longer durability are those more advanced in their development. Brolucizumab and abicipar pegol are 2 new anti-VEGF drugs that had positive results in phase 2 studies and are being tested in phase 3 trials at present. Other promising therapies are antiangiopoietin 2 molecules, which are in phase 2 development. At earlier stages of development but with promising results are squalamine, anti-VEGF-C and -D, and gene therapy. The future will give retina specialists a broad armamentarium with which patients may achieve high visual gains for the long term with a low treatment burden. Copyright © 2017 by Asia Pacific Academy of Ophthalmology.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.22608/APO.2017258
dc.identifier.issn21620989
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23066
dc.language.isoengspa
dc.publisherAsia-Pacific Academy of Ophthalmologyspa
dc.relation.citationEndPage519
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage514
dc.relation.citationTitleAsia-Pacific Journal of Ophthalmology
dc.relation.citationVolumeVol. 6
dc.relation.ispartofAsia-Pacific Journal of Ophthalmology, ISSN:21620989, Vol.6, No.6 (2017); pp. 514-519spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85038424836&doi=10.22608%2fAPO.2017258&partnerID=40&md5=aa8acc21b9807e91bad72bad0f50c009spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAngiogenesis inhibitorspa
dc.subject.keywordMonoclonal antibodyspa
dc.subject.keywordPlatelet derived growth factorspa
dc.subject.keywordVasculotropinspa
dc.subject.keywordAntagonists and inhibitorsspa
dc.subject.keywordClinical trial (topic)spa
dc.subject.keywordGene therapyspa
dc.subject.keywordHumanspa
dc.subject.keywordMacular degenerationspa
dc.subject.keywordProceduresspa
dc.subject.keywordSubretinal neovascularizationspa
dc.subject.keywordAngiogenesis inhibitorsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordChoroidal neovascularizationspa
dc.subject.keywordClinical trials as topicspa
dc.subject.keywordGenetic therapyspa
dc.subject.keywordHumansspa
dc.subject.keywordMacular degenerationspa
dc.subject.keywordPlatelet-derived growth factorspa
dc.subject.keywordVascular endothelial growth factorsspa
dc.subject.keywordAmdspa
dc.subject.keywordNeovascularspa
dc.subject.keywordNewspa
dc.subject.keywordTreatmentspa
dc.subject.keywordVegfspa
dc.titleNew treatment modalities for neovascular age-related macular degenerationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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