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Spleen lymphocyte function modulated by a cocoa-enriched diet

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dc.creatorRamiro Puig, E.spa
dc.creatorPérez Cano, F. J.spa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorCastellote, C.spa
dc.creatorIzquierdo Pulido, M.spa
dc.creatorPermanyer, J.spa
dc.creatorFranch, A.spa
dc.creatorCastell, M.spa
dc.date.accessioned2020-08-19T14:40:42Z
dc.date.available2020-08-19T14:40:42Z
dc.date.created2007-06-12spa
dc.description.abstractPrevious studies have shown the down?regulating in vitro effect of cocoa flavonoids on lymphocyte and macrophage activation. In the present paper, we report the capacity of a long?term rich cocoa diet to modulate macrophage cytokine secretion and lymphocyte function in young rats. Weaned rats received natural cocoa (4% or 10% food intake), containing 32?mg flavonoids/g, for 3?weeks. Spleen immune function was then evaluated through the analysis of lymphocyte composition, their proliferative response and their ability to secrete cytokines and Ig. In addition, the status of activated peritoneal macrophages was established through tumour necrosis factor (TNF)?? secretion. The richest cocoa diet (10%) caused a reduction of TNF?? secretion by peritoneal macrophages showing anti?inflammatory activity. Similarly, although a 10% cocoa diet increased lymphocyte proliferation rate, it down?regulated T helper 2 (Th2)?related cytokines and decreased Ig secretion. These changes were accompanied by an increase in spleen B cell proportion and a decrease in Th cell percentage. In summary, these results demonstrate the functional activity of a cocoa?high dosage in down?regulating the immune response that might be beneficial in hypersensitivity and autoimmunity.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1365-2249.2007.03430.x
dc.identifier.issnISSN: 0009-9104
dc.identifier.issnEISSN: 1365-2249
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26990
dc.language.isoengspa
dc.publisherBritish Society for Immunologyspa
dc.relation.citationEndPage542
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage535
dc.relation.citationTitleClinical and Experimental Immunology
dc.relation.citationVolumeVol. 149
dc.relation.ispartofClinical and Experimental Immunology, ISSN: 0009-9104;EISSN: 1365-2249, Vol.149, No.3 (September 2007); pp. 535-542spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2249.2007.03430.xspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceClinical and Experimental Immunologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCocoaspa
dc.subject.keywordCytokinesspa
dc.subject.keywordImmunoglobulinsspa
dc.subject.keywordLymphocytesspa
dc.subject.keywordSpleenspa
dc.titleSpleen lymphocyte function modulated by a cocoa-enriched dietspa
dc.title.TranslatedTitleFunción de los linfocitos del bazo modulada por una dieta enriquecida con cacaospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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