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Differences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 gene

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dc.creatorGonzález-Giraldo, Yeimyspa
dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.creatorMueller, Shane Tspa
dc.creatorPiper, Brian Jspa
dc.creatorAdan, Anaspa
dc.creatorForero, Diego Aspa
dc.date.accessioned2020-08-19T14:42:34Z
dc.date.available2020-08-19T14:42:34Z
dc.date.created2015spa
dc.description.abstractPerformance alterations in executive function have been studied as potential endophenotypes for several neuropsychiatric diseases. Planning is an important component of executive function and has been shown to be affected in diseases such as attention deficit hyperactivity disorder, schizophrenia, obsessive–compulsive disorder and Parkinson’s disease. Several genes related to dopaminergic systems, such as COMT, have been explored as candidates for influencing planning performance. The circadian clock gene PERIOD3 (PER3) has been shown to be associated with several complex behaviors in humans and could be involved in different signaling mechanisms. In this study, we evaluated the possible association between a functional polymorphism in the PER3 gene (PER3-VNTR, rs57875989) and performance in a commonly used test of planning (Tower of London, TOL) in 229 healthy subjects from Bogotá, Colombia. PER3-VNTR genotyping was carried out with conventional PCR and all participants completed the TOL test using the computerized Psychology Experiment Building Language (PEBL) battery. A linear regression model was used for the analysis of association with the SNPStats program. We found that 4/4 genotype carriers showed a better performance and made fewer moves, in comparison to 4/5 and 5/5 genotype carriers (p?=?0.003). These results appear to be independent from effects of this polymorphism on self-reported average hours of sleep during work days in our sample.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3109/07420528.2015.1014096
dc.identifier.issnISSN: 0742-0528
dc.identifier.issnEISSN: 1525-6073
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27525
dc.language.isoengspa
dc.publisherTaylor and Francisspa
dc.relation.citationEndPage595
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage591
dc.relation.citationTitleChronobiology International, Annual Review of Chronopharmacology
dc.relation.citationVolumeVol. 32
dc.relation.ispartofChronobiology International, Annual Review of Chronopharmacology, ISSN: 0742-0528; EISSN: 1525-6073, Vol.32, No.5 (2015); pp.591-595spa
dc.relation.urihttps://www.tandfonline.com/doi/abs/10.3109/07420528.2015.1014096?journalCode=icbi20spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceChronobiology International, Annual Review of Chronopharmacologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCandidate genespa
dc.subject.keywordChronobiologyspa
dc.subject.keywordCognitionspa
dc.subject.keywordNeurogeneticsspa
dc.subject.keywordPsychiatric geneticsspa
dc.titleDifferences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 genespa
dc.title.TranslatedTitleLas diferencias en el desempeño de la planificación, un endofenotipo neurocognitivo, están asociadas con una variante funcional en el gen PER3spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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