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A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis

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dc.creatorGómez, Luis Miguelspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorVilchez, José Ramónspa
dc.creatorCadena, Josespa
dc.creatorHinojosa, Rosaspa
dc.creatorVélez, Lucianospa
dc.creatorLopez-Nevot, Miguel Angelspa
dc.creatorMartín, Javierspa
dc.date.accessioned2020-05-26T00:01:43Z
dc.date.available2020-05-26T00:01:43Z
dc.date.created2007spa
dc.description.abstractiNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.tube.2007.03.002
dc.identifier.issn14729792
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23399
dc.language.isoengspa
dc.relation.citationEndPage294
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage288
dc.relation.citationTitleTuberculosis
dc.relation.citationVolumeVol. 87
dc.relation.ispartofTuberculosis, ISSN:14729792, Vol.87, No.4 (2007); pp. 288-294spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34250656205&doi=10.1016%2fj.tube.2007.03.002&partnerID=40&md5=22d286ccdd393e39aa3dca54851a700bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordpulmonaryeng
dc.subject.keywordInducible nitric oxide synthasespa
dc.subject.keywordTuberculinspa
dc.subject.keywordAdultspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordEndemic diseasespa
dc.subject.keywordFemalespa
dc.subject.keywordGene locationspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenetic traitspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordInfection riskspa
dc.subject.keywordLong terminal repeatspa
dc.subject.keywordLung tuberculosisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSample sizespa
dc.subject.keywordShort tandem repeatspa
dc.subject.keywordSkin testspa
dc.subject.keywordAdultspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordNitric oxide synthase type iispa
dc.subject.keywordSeroepidemiologic studiesspa
dc.subject.keywordTandem repeat sequencesspa
dc.subject.keywordTuberculosiseng
dc.subject.keywordGeneticsspa
dc.subject.keywordNitric oxide synthasesspa
dc.subject.keywordTuberculosisspa
dc.titleA polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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