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Cannabinoids for major neurocognitive disorder: case report and literature review

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dc.creatorGómez, Paula M. Herreraspa
dc.creatorOchoa-Orozco, Sergio A.spa
dc.creatorToro, Carolina Jaramillospa
dc.date.accessioned2020-05-25T23:59:27Z
dc.date.available2020-05-25T23:59:27Z
dc.date.created2020spa
dc.description.abstractIntroduction: Major neurocognitive disorder (MNCD) affects millions of people worldwide. However, the pharmacological options for its management are limited, ineffective and frequently associated with severe adverse reactions. Case report: An 85-year-old man with history of multiple chronic brain injuries (alcohol-use disorder, haemorrhagic stroke, brain trauma, chronic use of benzodiazepines) developed an MNCD, reaching 7 points on the Reisberg Global Deterioration Scale. He had minimal response to antidepressants, antipsychotics and anticholinergic medications. After the use of mother tincture of Indian hemp (cannabis), a significant improvement was found in his cognitive function, ability to carry out activities of daily living and independence. Discussion: The endocannabinoid system seems to be implicated in age-related cognitive decline. In addition, the evidence derived from in-vitro and animal models suggest that this system could play an important role in the management of MNCD of different causes. Conclusions: Cannabinoid treatment for MNCD emerges as a promising therapeutic approach that may benefit a growing number of patients who do not have other treatment options. It is therefore necessary to encourage more research efforts that will help to remove political and scientific barriers to its clinical use. © 2019 Asociación Colombiana de Psiquiatríaeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.rcp.2019.07.002
dc.identifier.issn347450
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23048
dc.language.isoengspa
dc.publisherElsevier Doymaspa
dc.relation.citationTitleRevista Colombiana de Psiquiatria
dc.relation.ispartofRevista Colombiana de Psiquiatria, ISSN:347450,(2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078858728&doi=10.1016%2fj.rcp.2019.07.002&partnerID=40&md5=7a046251603d7d2978d8d8031a9ead67spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCannabinoidsspa
dc.subject.keywordCannabis indicaspa
dc.subject.keywordDementiaspa
dc.subject.keywordMajor neurocognitive disorderspa
dc.titleCannabinoids for major neurocognitive disorder: case report and literature reviewspa
dc.title.TranslatedTitleUso de Cannabinoides en Trastorno Neurocognitivo Mayor: Reporte de un caso y Revisión de la Literaturaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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