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Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry

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dc.creatorGicchino, Francescaspa
dc.creatorBarone, Patriziaspa
dc.creatorDel Giudice, Emanuelaspa
dc.creatorInsalaco, Antonellaspa
dc.creatorErten, S¸ükranspa
dc.creatorÖnen, Fatosspa
dc.creatorCiavarro, Alessandrospa
dc.creatorRigante, Donatospa
dc.creatorAragona, Emmaspa
dc.creatorMaggio, Maria Cristinaspa
dc.creatorGuiducci, Serenaspa
dc.creatorShahram, Farhadspa
dc.creatorMejía-Salgado, Germánspa
dc.creatorde la Torre Cifuentes, Ligia Alejandraspa
dc.creatorWiesik-Scewczyk, Ewaspa
dc.creatorLa Torre, Francescospa
dc.creatorCarreno, Esterspa
dc.creatorDe Paulis, Amatospa
dc.creatorBreda, Lucianaspa
dc.creatorSarzi Puttini, Piercarlospa
dc.creatorParronchi, Paolaspa
dc.creatorLi Gobbi, Francescaspa
dc.creatorGiardina, Annaritaspa
dc.creatorMaier, Arminspa
dc.creatorConti, Giovannispa
dc.creatorGunduz, Ozgul Soysalspa
dc.creatorAkkoc, Nurullahspa
dc.creatorBartoloni, Elenaspa
dc.creatorCattalini, Marcospa
dc.creatorConforti, Alessandrospa
dc.creatorCosti, Stefaniaspa
dc.creatorOpris-Belinski, Danielaspa
dc.creatorSener, Seherspa
dc.creatorOzen, Sezaspa
dc.creatorBatu, Ezgi Denizspa
dc.creatorSebastiani, Gian Domenicospa
dc.creatorS¸ahin, Alispa
dc.creatorViapiana, Ombrettaspa
dc.creatorEmmi, Giacomospa
dc.creatorCiccia, Francescospa
dc.creatorThabet, Maissaspa
dc.creatorTharwat, Samarspa
dc.creatorGiacomelli, Robertospa
dc.creatorFrassi, Micolspa
dc.creatorKarakoc, Alicanspa
dc.creatorHatemi, Gülenspa
dc.creatorMonti, Saraspa
dc.creatorTarsia, Mariaspa
dc.creatorLopez, Robertaspa
dc.creatorCaggiano, Valeriaspa
dc.creatorVitale, Antoniospa
dc.creatorGaggiano, Carlaspa
dc.creatorGentileschi, Stefanospa
dc.creatorEspinosa, Gerardspa
dc.creatorAlunno, Alessiaspa
dc.creatorBellis, Elisaspa
dc.creatorRuffilli, Francescaspa
dc.creatorGentile, Martinaspa
dc.creatorFloris, Albertospa
dc.creatorArida, Katerinaspa
dc.creatorChimenti, Maria Solespa
dc.creatorDammacco, Rosannaspa
dc.creatorAntonelli, Isabelle Parente de Britospa
dc.creatorKawakami-Campos, Perla Ayumispa
dc.creatorTorres-Ruiz, Jiramspa
dc.creatorSevik, Gizemspa
dc.creatorÖner, Fatma Alibazspa
dc.creatorKardas, Rizaspa
dc.creatorKucuk, Hamitspa
dc.creatorSpedicato, Veronicaspa
dc.creatorMorrone, Mariaspa
dc.creatorAlanazi, Fehaidspa
dc.creatorAsfina, Kazi Nurspa
dc.creatorAboabat, Aos A.spa
dc.creatorGhanem, Mahmoudspa
dc.creatorMahmoud, Ayman Abdel-Monem Ahmedspa
dc.creatorLaymouna, Ahmed Hatemspa
dc.creatorHernández-Rodríguez, Joséspa
dc.creatorCarubbi, Francescospa
dc.creatorIagnocco, Annamariaspa
dc.creatorGovoni, Marcellospa
dc.creatorRuscitti, Pierospa
dc.creatorPiga, Matteospa
dc.creatorCantarinispa
dc.creatorFabiani, Claudiaspa
dc.creatorFrediani, Brunospa
dc.creatorMazzei, Maria Antoniettaspa
dc.creatorBalistreri, Albertospa
dc.creatorKaramanakos, Anastasiosspa
dc.creatorMauro, Angelaspa
dc.creatorLo Gullo, Albertospa
dc.creatorBrucato, Antoniospa
dc.creatorSfikakis, Petros P.spa
dc.creatorTriggianese, Paolaspa
dc.creatorGuerriero, Silvanaspa
dc.creatorGiardini, Henrique Ayres Mayrinkspa
dc.creatorHinojosa-Azaola, Andreaspa
dc.creatorDireskeneli, Hanerspa
dc.creatorTufan, Abdurrahmanspa
dc.creatorLopalco, Giuseppespa
dc.creatorAlMaglouth, Ibrahimspa
dc.creatorRagab, Gaafarspa
dc.creatorSota, Jurgenspa
dc.date.accessioned2025-07-21T16:48:10Z
dc.date.available2025-07-21T16:48:10Z
dc.date.created2025-03-01spa
dc.date.issued2025-03-01spa
dc.description.abstractObjectives: Gender impact on phenotypical expression of Behc¸ et’s disease (BD) has been specifically investigated only in a few large-scale studies. The main goal of the study was to examine gender differences in a large cohort of patients affected by BD. Methods. – Data were retrieved from the International AIDA Network Registry for BD. We assessed differences between males and females in terms of Behc¸ et’s syndrome Overall Damage Index (BODI), differences in the disease manifestations at onset and in the cumulative manifestations throughout disease course, as well as differences in the cardiovascular risk. Finally, predictive factors leading to major organ involvement were investigated. Results. – In total, 1024 BD patients (567 males, 457 females) were enrolled in the study, with a male-to-female ratio of 1.24/1. Males displayed a significantly higher mean ± SD BODI (1.92 ± 2.09) at the last follow-up, compared to female patients (1.25 ± 1.87) (P < 0.0001). Uveitis (P < 0.0001) and vascular involvement (P = 0.0076) were significantly more frequent among males whereas female patients were significantly over-represented in arthralgia (P < 0.0001), arthritis (P = 0.00025), isolated headache (P < 0.0001), central nervous system (CNS) involvement (P = 0.040), and gastrointestinal involvement (P = 0.00046). Regarding cardiovascular risk, no differences between the two groups emerged (P = 0.617). Four variables were associated with the development of major organ involvement: male gender (OR = 2.104, P = 0.001), current treatment with biologic agents (OR = 2.257, P = 0.0003), origin from endemic countries (OR = 2.661, P = 0.0009), and disease duration (OR = 1.002, P = 0.024). Conclusion. – BD displays a more severe course among males. This subgroup develops more irreversible damage and presents more frequently ocular and vascular involvement during disease course. On the other hand, female patients are prone to experience articular involvement, headache, CNS and gastrointestinal involvement. These data suggest the existence of a gender-driven disease expression.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.jbspin.2024.105819spa
dc.identifier.issn1297-319Xspa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46082
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.ispartofJoint Bone Spine Volume 92, Issue 2, March 2025spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1297319X24001301?via%3Dihubspa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceJoint Bone Spinespa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordReumatologíaeng
dc.subject.keywordBehcet’s diseaseeng
dc.subject.keywordGendereng
dc.subject.keywordRegistryeng
dc.subject.keywordAutoinflammatoryeng
dc.subject.keywordOrgan damageeng
dc.titleInfluence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registryspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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