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Opioids in the management of pain in diabetic neuropathy

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dc.creatorMoreno C.B.spa
dc.creatorGutiérrez-Álvarez A.M.spa
dc.date.accessioned2020-05-25T23:58:30Z
dc.date.available2020-05-25T23:58:30Z
dc.date.created2010spa
dc.description.abstractNeuropathy is one of the most frequent complications of diabetes and pain, one of its more common and incapacitating symptoms. Recently there are reports of the use of opioids as an alternative of analgesic treatment. Objective: this work's objective has been to carry out a systematic review for determining the opioids power for managing pain in patients suffering from painful diabetic neuropathy. Methodology: a search and systematic selection was carried out of all clinical assays concerning the analgesic treatment of diabetic neuropathy using opioids published from January 1998 to June 2009. Randomized clinical trials compared with placebo were included which studied the analgesic effect of opioids in adults suffering from painful diabetic neuropathy; they were evaluated so that improvement of pain could be objectively classified. Results: there were nine randomized clinical trials identified. Only five were finally included: two with tramadol and three with oxycodone. The data provided by these studies did not allow to perform a meta-analysis. Conclusions: the improvement of pain in patients treated with tramadol or oxicodone was statistically significant superior when compared to placebo. It is necessary to make future clinical randomized studies to evaluate the analgesic effectiveness of opioids in painful diabetic neuropathy, including the magnitude of individual improvement, the previous definition of the percentage of improvement that is considered clinically significant and a longer time of follow-up. ©INNN, 2010.spa
dc.format.mimetypeapplication/pdf
dc.identifier.issn10285938
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22877
dc.language.isospaspa
dc.relation.citationEndPage34
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage31
dc.relation.citationTitleArchivos de Neurociencias
dc.relation.citationVolumeVol. 15
dc.relation.ispartofArchivos de Neurociencias, ISSN:10285938, Vol.15, No.1 (2010); pp. 31-34spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78650214195&partnerID=40&md5=e4b2c4993f83b947a54a633c298f0a78spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordOpiatespa
dc.subject.keywordOxycodonespa
dc.subject.keywordPlacebospa
dc.subject.keywordTramadolspa
dc.subject.keywordAnalgesiaspa
dc.subject.keywordAnalgesic activityspa
dc.subject.keywordArticlespa
dc.subject.keywordClinical trialspa
dc.subject.keywordDiabetic neuropathyspa
dc.subject.keywordDiabetic patientspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug usespa
dc.subject.keywordFollow upspa
dc.subject.keywordHumanspa
dc.subject.keywordNeuropathic painspa
dc.subject.keywordAnalgesicsspa
dc.subject.keywordDiabetic neuropathyspa
dc.subject.keywordOpioidsspa
dc.subject.keywordPainspa
dc.titleOpioids in the management of pain in diabetic neuropathyspa
dc.title.TranslatedTitleOpioides en el manejo del dolor en la neuropatía diabéticaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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