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ADHD Endophenotypes in Caribbean Families

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dc.creatorCervantes-Henríquez, M Lspa
dc.creatorAcosta-López, J Espa
dc.creatorMartínez-Banfi, M Lspa
dc.creatorVélez, J Ispa
dc.creatorMejía-Segura, Espa
dc.creatorLozano-Gutiérrez, S Gspa
dc.creatorSánchez-Rojas, Mspa
dc.creatorZurbarán, M Aspa
dc.creatorZurek, E Espa
dc.creatorArcos-Burgos, Mspa
dc.creatorPineda, D Aspa
dc.creatorPuentes-Rozo, P Jspa
dc.date.accessioned2020-05-25T23:55:51Z
dc.date.available2020-05-25T23:55:51Z
dc.date.created2018spa
dc.description.abstractObjective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. © 2018, The Author(s) 2018.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1177/1087054718763741
dc.identifier.issn10870547
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22241
dc.language.isoengspa
dc.publisherSAGE Publications Inc.spa
dc.relation.citationTitleJournal of Attention Disorders
dc.relation.ispartofJournal of Attention Disorders, ISSN:10870547,(2018)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044936738&doi=10.1177%2f1087054718763741&partnerID=40&md5=6c7bf18fc686a54ab2b7aa7208ed2a99spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdhdspa
dc.subject.keywordAttentionspa
dc.subject.keywordEndophenotypesspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHeritabilityspa
dc.subject.keywordMemoryspa
dc.titleADHD Endophenotypes in Caribbean Familiesspa
dc.typecontributionToPeriodicaleng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDiariospa
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