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NHP-immunome: A translational research-oriented database of non-human primate immune system proteins

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dc.creatorPlaza, David F.spa
dc.creatorGómez, Manuel F.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:03:59Z
dc.date.available2020-05-26T00:03:59Z
dc.date.created2020spa
dc.description.abstractWe are currently living the advent of a new age for medicine in which basic research is being quickly translated into marketable drugs, and the widespread access to genomics data is allowing the design and implementation of personalized solutions to medical conditions. Non-human primates (NHP) have gained an essential role in drug discovery and safety testing due to their close phylogenetic relationship to humans. In this study, a collection of well characterized genes of the human immune system was used to define the orthology-based immunome in four NHP species, with carefully curated annotations available based on multi-tissue RNA-seq datasets. A broad variation in the frequency of expressed protein isoforms was observed between species. Finally, this analysis also revealed the lack of expression of at least four different chemokines in new-world primates. In addition, transcripts corresponding to four genes including interleukin 12 subunit alpha were expressed in humans but no other primate species analyzed. Access to the non-human primate immunome is available in http://www.fidic.org.co:90/proyecto/. © 2019 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cellimm.2019.103999
dc.identifier.issn10902163
dc.identifier.issn00088749
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23646
dc.language.isoengspa
dc.publisherAcademic Press Inc.spa
dc.relation.citationTitleCellular Immunology
dc.relation.citationVolumeVol. 347
dc.relation.ispartofCellular Immunology, ISSN:10902163, 00088749, Vol.347,(2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85075445785&doi=10.1016%2fj.cellimm.2019.103999&partnerID=40&md5=beae1806ee3f264f689ec0547499448espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordInterleukin 12p35spa
dc.subject.keywordIsoproteinspa
dc.subject.keywordAotus nancymaaespa
dc.subject.keywordArticlespa
dc.subject.keywordCallithrix jacchusspa
dc.subject.keywordDrug safetyspa
dc.subject.keywordGene expressionspa
dc.subject.keywordGenetic transcriptionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune systemspa
dc.subject.keywordMolecular phylogenyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPan troglodytesspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPrimatespa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordRhesus monkeyspa
dc.subject.keywordRna analysisspa
dc.subject.keywordRna sequencespa
dc.subject.keywordTranslational researchspa
dc.subject.keywordAotus nancymaaespa
dc.subject.keywordCallithrix jacchusspa
dc.subject.keywordImmune system orthologyspa
dc.subject.keywordMacaca mulattaspa
dc.subject.keywordPan troglodytesspa
dc.subject.keywordSplicing/protein isoformsspa
dc.titleNHP-immunome: A translational research-oriented database of non-human primate immune system proteinsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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