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Prevalence, clinical outcomes and rainfall association of acute respiratory infection by human metapneumovirus in children in Bogotá, Colombia

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dc.creatorEvelyn, Obandospa
dc.creatorJaime, Fernández-Sarmientospa
dc.creatorDavid, Montoyaspa
dc.creatorLorena, Acevedospa
dc.creatorJenifer, Arroyavespa
dc.creatorOscar, Gamboaspa
dc.date.accessioned2020-05-26T00:03:17Z
dc.date.available2020-05-26T00:03:17Z
dc.date.created2019spa
dc.description.abstractBackground: Acute respiratory infections (ARIs) are one of the main causes of morbidity and mortality in children. Viruses are the main etiological agents, and their behavior tends to be seasonal and vary by geographical location. Human metapneumovirus (HMPV) has recently been described as a cause of severe acute respiratory infection and its prevalence and clinical behavior in children at moderate altitudes is unknown. Methods: A cross-sectional study was carried out on patients seen at a university hospital in Bogotá, Colombia between October 2015 and December 2017 in a city at a moderate altitude above sea level. Children with acute respiratory infections who had had a multiplex RT-PCR assay were selected. The prevalence of HMPV infection, its clinical outcomes and its relationship to rainfall were evaluated. Results: Out of a total of 14,760 discharged patients, multiplex RT-PCR was performed on 502 and a virus was detected in 420 children with acute respiratory infection (ARI). The study group had a median age of 21 months (IQR 7-60), with similar proportion of males and females (56.4 and 43.6% respectively) and 5.2% (CI 95 3.3-7.8%) prevalence of HMPV infection. The group with HMPV infection showed a greater frequency of viral coinfection (22.7% vs 14% P = 0.03) compared with ARI caused by other viruses. The rate of bacterial coinfection (P = 0.31), presence of comorbidities (p = 0.75), length of hospital stay (P = 0.42), need for mechanical ventilation (P = 0.75) and mortality (P = 0.22) were similar for HMPV and other viral infections. A moderate correlation was established between HMPV infection and rainfall peaks (Spearman's Rho 0.44 p = 0.02). Conclusions: Human metapneumovirus was the fifth most frequently isolated virus in children with ARI, had similar clinical behavior and severity to other viruses but a higher rate of viral coinfection. Its peaks seem to correlate to rainy seasons. © 2019 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12887-019-1734-x
dc.identifier.issn14712431
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23577
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Pediatrics
dc.relation.citationVolumeVol. 19
dc.relation.ispartofBMC Pediatrics, ISSN:14712431, Vol.19, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073118191&doi=10.1186%2fs12887-019-1734-x&partnerID=40&md5=f49766c9b7b09c00d1213ea7b8ab7f69spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordRainspa
dc.subject.keywordAdenoviridaespa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordArtificial ventilationspa
dc.subject.keywordBronchiolitisspa
dc.subject.keywordColombiaspa
dc.subject.keywordComorbidityspa
dc.subject.keywordCongenital heart diseasespa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordDisease severityspa
dc.subject.keywordEnterovirusspa
dc.subject.keywordFemalespa
dc.subject.keywordGroups by agespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman metapneumovirusspa
dc.subject.keywordHuman metapneumovirus infectionspa
dc.subject.keywordHuman parainfluenza virus 3spa
dc.subject.keywordKidney diseasespa
dc.subject.keywordLength of stayspa
dc.subject.keywordLiver diseasespa
dc.subject.keywordLung dysplasiaspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMalignant neoplasmspa
dc.subject.keywordMalnutritionspa
dc.subject.keywordMixed infectionspa
dc.subject.keywordMortalityspa
dc.subject.keywordMultiplex polymerase chain reactionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPediatric patientspa
dc.subject.keywordPneumoniaspa
dc.subject.keywordPopulation researchspa
dc.subject.keywordPrematurityspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRespiratory tract infectionspa
dc.subject.keywordRhinopharyngitisspa
dc.subject.keywordRhinovirusspa
dc.subject.keywordSeasonal variationspa
dc.subject.keywordSex ratiospa
dc.subject.keywordVirus detectionspa
dc.subject.keywordVirus isolationspa
dc.subject.keywordChildrenspa
dc.subject.keywordPneumoniaspa
dc.subject.keywordRespiratory syncytial virusspa
dc.subject.keywordViral infectionspa
dc.titlePrevalence, clinical outcomes and rainfall association of acute respiratory infection by human metapneumovirus in children in Bogotá, Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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