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Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides

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dc.creatorCurtidor, Hernandospa
dc.creatorRodríguez, Luis Espa
dc.creatorOcampo, Marisolspa
dc.creatorLópez, Ramsesspa
dc.creatorGarcía, Javier Espa
dc.creatorValbuena, Johnspa
dc.creatorVera, Ricardospa
dc.creatorPuentes, Alvarospa
dc.creatorVanegas, Magnoliaspa
dc.creatorPatarroyo, Manuel Espa
dc.date.accessioned2020-08-19T14:40:41Z
dc.date.available2020-08-19T14:40:41Z
dc.date.created2005-02spa
dc.description.abstractErythrocyte binding ligand 1 (EBL-1) is a member of the ebl multigene family involved in Plasmodiumfalciparum invasion of erythrocytes. We found that five EBL-1 high-activity binding peptides (HABPs)bound specifically to erythrocytes: 29895 (41HKKKSGELNNNKSGILRSTY60), 29903 (201LYECGK-KIKEMKWICTDNQF220), 29923 (601CNAILGSYADIGDIVRGLDV620), 29924(621WRDINTNKLSEK-FQKIFMGGY640), and 30018 (2481LEDIINLSKKKKKSINDTSFY2500). We also show that binding wassaturable, not sialic acid-dependent, and that all peptides specifically bound to a 36-kDa protein on theerythrocyte membrane. The five HABPs inhibited in vitro merozoite invasion depending on the peptideconcentration used, suggesting their possible role in the invasion process.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1110/ps.041084305
dc.identifier.issnISSN: 0961-8368
dc.identifier.issnEISSN: 1469-896X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26987
dc.language.isoengspa
dc.publisherThe Protein Societyspa
dc.publisherJohn Wiley & Sonspa
dc.relation.citationEndPage473
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage464
dc.relation.citationTitleProtein Science
dc.relation.citationVolumeVol. 14
dc.relation.ispartofProtein Science, ISSN: 0961-8368;EISSN: 1469-896X, Vol.14, No.2 (February 2005); pp. 464-473spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1110/ps.041084305spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceProtein Sciencespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMalaria proteinspa
dc.subject.keywordErythrocyte binding ligand-1spa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.titleSpecific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptidesspa
dc.title.TranslatedTitleCapacidad de unión a eritrocitos específica y actividad biológica de péptidos derivados del ligando 1 de unión a eritrocitos de Plasmodium falciparum (EBL-1)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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