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The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaic

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dc.creatorAgmon-Levin N.spa
dc.creatorDagan A.spa
dc.creatorPeri Y.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorSelmi C.spa
dc.creatorTincani A.spa
dc.creatorBizzaro N.spa
dc.creatorStojanovich L.spa
dc.creatorDamoiseaux J.spa
dc.creatorTervaert J.W.C.spa
dc.creatorMosca M.spa
dc.creatorCervera R.spa
dc.creatorShoenfeld Y.spa
dc.date.accessioned2020-05-26T00:04:17Z
dc.date.available2020-05-26T00:04:17Z
dc.date.created2017spa
dc.description.abstractObjective The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies Methods We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. All samples were also tested for a variety of anti-infectious agents' antibodies using the BioPlex 2200-immunoassay (Bio-Rad, USA). Results Anti-Ro/SSA was more prevalent, with significantly higher titre in 5 autoimmune diseases namely Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) both primary and APS linked to SLE, systemic sclerosis (SSc) and primary biliary cirrhosis (PBC). Anti-La/SSB was more prevalent with higher titers in SS, SLE, APS linked to SLE and PBC. Prevalence, but not titers, of both antibodies were higher also in polymyositis (PM). Additionally, we found a correlation between anti-Ro/SSA antibodies and antibodies of the IgM and IgG subtypes directed at cytomegalovirus as well as IgG-antibodies directed at Epstein-Barr virus (EBV) and toxoplasma (p less than 0.001). Anti-La/SSB antibodies correlated with the presence of IgG antibodies against EBV early antigen (p less than 0.001). Conclusion In a large cohort of patients with autoimmune diseases we found an association between anti-Ro/SSA and anti-La/SSB antibodies and 6 autoimmune diseases, amongst which primary APS and PM. Additionally, we observed linkages between these autoantibodies and anti-infectious antibodies directed at Epstein-Barr virus, toxoplasma and cytomegalovirus. Our findings support the concept of interplay between infectious agents and autoimmunity, such as the plausibility of an infectious agent that trigger the immune system to produce specific antibodies which will later result in a unique group of AID. © Clinical and Experimental Rheumatology 2017.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0392856X
dc.identifier.issn1593098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23672
dc.language.isoengspa
dc.publisherClinical and Experimental Rheumatology S.A.S.spa
dc.relation.citationEndPage935
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage929
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 35
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN:0392856X, 1593098X, Vol.35, No.6 (2017); pp. 929-935spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040602055&partnerID=40&md5=eba2bf7a81f25f515ee4da9b467e8b86spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEarly antigenspa
dc.subject.keywordsystemiceng
dc.subject.keywordantinucleareng
dc.subject.keywordviraleng
dc.subject.keywordbiliaryeng
dc.subject.keywordhumaneng
dc.subject.keywordprotozoaneng
dc.subject.keywordImmunoglobulin g antibodyspa
dc.subject.keywordImmunoglobulin m antibodyspa
dc.subject.keywordLa antibodyspa
dc.subject.keywordRo antibodyspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAutoantigenspa
dc.subject.keywordProtozoon antibodyspa
dc.subject.keywordRibonucleoproteinspa
dc.subject.keywordSs-a antibodiesspa
dc.subject.keywordSs-b antigenspa
dc.subject.keywordVirus antibodyspa
dc.subject.keywordAnca associated vasculitisspa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordCryoglobulinemiaspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordEpstein barr virusspa
dc.subject.keywordGeographyspa
dc.subject.keywordGiant cell arteritisspa
dc.subject.keywordHepatitis cspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunoassayspa
dc.subject.keywordInflammatory bowel diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPolymyositisspa
dc.subject.keywordPrevalencespa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordWegener granulomatosisspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordBiliary cirrhosisspa
dc.subject.keywordBloodspa
dc.subject.keywordImmunologyspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntibodieseng
dc.subject.keywordAntibodieseng
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordCohort studiesspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordHerpesvirus 4eng
dc.subject.keywordHumansspa
dc.subject.keywordLiver cirrhosiseng
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordRibonucleoproteinsspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordAnti-la/ssb antibodyspa
dc.subject.keywordAnti-ro/ssa antibodyspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleThe interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: Another angle of the autoimmune mosaicspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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