Ítem
Solo Metadatos

Prevalence of Trypanosoma cruzi's Discrete Typing Units in a cohort of Latin American migrants in Spain

Mostrar el registro sencillo de la publicación
dc.creatorMartinez-Perez, Angelaspa
dc.creatorPoveda, Cristinaspa
dc.creatorRamírez, Juan Davidspa
dc.creatorNorman, Francescaspa
dc.creatorGironés, Núriaspa
dc.creatorGuhl, Felipespa
dc.creatorMonge-Maillo, Begoñaspa
dc.creatorFresno, Manuelspa
dc.creatorLópez-Vélez, Rogeliospa
dc.date.accessioned2020-05-26T00:04:03Z
dc.date.available2020-05-26T00:04:03Z
dc.date.created2016spa
dc.description.abstractChagas disease is caused by the protozoan Trypanosoma cruzi. This is an endemic disease in the Americas, but increased migration to Europe has made it emerge in countries where it was previously unknown, being Spain the second non endemic country in number of patients. T. cruzi is a parasite with a wide genetic diversity, which has been grouped by consensus into 6 Discrete Typing Units (DTUs) affecting humans. Some authors have linked these DTUs either to a specific epidemiological context or to the different clinical presentations. Our main objective was to describe the T. cruzi DTUs identified from a population of chronically infected Latin American migrants attending a reference clinic in Madrid. 149 patients meeting this condition were selected for the study. Molecular characterization was performed by an algorithm that combines PCR of the intergenic region of the mini exon-gene, the 24S? and 18S regions of rDNA and the variable region of the satellite DNA. A descriptive analysis was performed and associations between geographical/clinical data and the different DTUs were tested. DTUs could be determined in 105 out of 149 patients, 93.3% were from Bolivia, 67.7% were women and median age was 35 years (IQR 29-44). The most common DTU found was TcV (58; 55.2%), followed by TcIV (17; 16.2%), TcII (10; 9.5%) and TcI (4; 3.8%). TcIII and TcVI were not identified from any patient, and 15.2% patients presented mixed infections. In addition, we determined DTUs after treatment in a subset of patients. In 57% patients had different DTUs before and after treatment. DTUs distribution from this study indicates active transmission of T. cruzi is occurring in Bolivia, in both domestic and sylvatic cycles. TcIV was confirmed as a cause of chronic human disease. The current results indicate no correlation between DTU and any specific clinical presentation associated with Chagas disease, nor with geographical origin. Treatment with benznidazole does not always clear T. cruzi's genetic material from blood, and DTUs detected in the same patient may vary over time indicating that polyparasitism is frequent. © 2016 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2016.01.032
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23652
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage150
dc.relation.citationStartPage145
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 157
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.157,(2016); pp. 145-150spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84957875595&doi=10.1016%2fj.actatropica.2016.01.032&partnerID=40&md5=4f5710260d7a84228046695aa0e8f76aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBenznidazolespa
dc.subject.keywordNifurtimoxspa
dc.subject.keywordAlgorithmspa
dc.subject.keywordBloodspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordDisease prevalencespa
dc.subject.keywordDisease spreadspa
dc.subject.keywordEndemismspa
dc.subject.keywordGenomespa
dc.subject.keywordPopulation migrationspa
dc.subject.keywordAdultspa
dc.subject.keywordAlgorithmspa
dc.subject.keywordArticlespa
dc.subject.keywordBoliviaspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiscrete typing unitspa
dc.subject.keywordDrug substitutionspa
dc.subject.keywordDrug withdrawalspa
dc.subject.keywordExonspa
dc.subject.keywordFemalespa
dc.subject.keywordGeographic originspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMigrantspa
dc.subject.keywordParasite transmissionspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordProtozoal geneticsspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordSpainspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordUnspecified side effectspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordEndemic diseasespa
dc.subject.keywordEthnologyspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordMigrationspa
dc.subject.keywordMolecular typingspa
dc.subject.keywordStatistics and numerical dataspa
dc.subject.keywordTransmissionspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordLatin americaspa
dc.subject.keywordMadrid [spain]spa
dc.subject.keywordSpainspa
dc.subject.keywordProtozoaspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordAdultspa
dc.subject.keywordBoliviaspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordCohort studiesspa
dc.subject.keywordCoinfectionspa
dc.subject.keywordEndemic diseasesspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMolecular typingspa
dc.subject.keywordPrevalencespa
dc.subject.keywordSpainspa
dc.subject.keywordTransients and migrantsspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordChagas diseasespa
dc.subject.keywordDiscrete typing unitsspa
dc.subject.keywordGenomespa
dc.subject.keywordMigrationspa
dc.subject.keywordTrypanosoma cruzispa
dc.titlePrevalence of Trypanosoma cruzi's Discrete Typing Units in a cohort of Latin American migrants in Spainspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos