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Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa

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dc.creatorFaria, Nuno R.spa
dc.creatorVidal, Nicolespa
dc.creatorLourenco, Joséspa
dc.creatorRaghwani, Jaynaspa
dc.creatorSigaloff, Kim C. E.spa
dc.creatorTatem, Andy J.spa
dc.creatorvan de Vijver, David A. M.spa
dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorRose, Rebeccaspa
dc.creatorWallis, Carole L.spa
dc.creatorAhuka-Mundeke, Stevespa
dc.creatorMuyembe-Tamfum, Jean-Jacquesspa
dc.creatorMuwonga, Jérémiespa
dc.creatorSuchard, Marc A.spa
dc.creatorde Wit, Tobias F. Rinkespa
dc.creatorHamers, Raph L.spa
dc.creatorNdembi, Nicaisespa
dc.creatorBaele, Guyspa
dc.creatorPeeters, Martinespa
dc.creatorPybus, Oliver G.spa
dc.creatorLemey, Philippespa
dc.creatorDellicour, Simonspa
dc.date.accessioned2020-05-25T23:58:20Z
dc.date.available2020-05-25T23:58:20Z
dc.date.created2019spa
dc.description.abstractSince the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary circumstances that contributed to its epidemiological expansion remain poorly understood. Here, we analyse 346 novel pol sequences from the DRC to compare the evolutionary dynamics of the main HIV-1 lineages, subtypes A1, C and D. Our results place the origins of subtype C in the 1950s in Mbuji-Mayi, the mining city of southern DRC, while subtypes A1 and D emerged in the capital city of Kinshasa, and subtypes H and J in the less accessible port city of Matadi. Following a 15-year period of local transmission in southern DRC, we find that subtype C spread at least three-fold faster than other subtypes circulating in Central and East Africa. In conclusion, our results shed light on the origins of HIV-1 main lineages and suggest that socio-historical rather than evolutionary factors may have determined the epidemiological fate of subtype C in sub-Saharan Africa. © 2019 Faria et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1007976
dc.identifier.issn15537374
dc.identifier.issn15537366
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22841
dc.language.isoengspa
dc.publisherPublic Library of Sciencespa
dc.relation.citationIssueNo. 12
dc.relation.citationTitlePLoS Pathogens
dc.relation.citationVolumeVol. 15
dc.relation.ispartofPLoS Pathogens, ISSN:15537374, 15537366, Vol.15, No.12 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85076317941&doi=10.1371%2fjournal.ppat.1007976&partnerID=40&md5=3e4aaf8f37701e76ea3fb70fcb46a0fbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordVirus RNAspa
dc.subject.keywordAntiretroviral therapyspa
dc.subject.keywordAntiviral resistancespa
dc.subject.keywordArticlespa
dc.subject.keywordBayes theoremspa
dc.subject.keywordBiogeographyspa
dc.subject.keywordBioinformaticsspa
dc.subject.keywordCorrelation analysisspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordGenetic recombinationspa
dc.subject.keywordGeographic distributionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1 infectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMarkov chainspa
dc.subject.keywordMaximum likelihood methodspa
dc.subject.keywordMolecular clockspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordNested polymerase chain reactionspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPhylogeographyspa
dc.subject.keywordPopulation growthspa
dc.subject.keywordRNA sequencespa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordSeroprevalencespa
dc.subject.keywordVirus isolationspa
dc.subject.keywordAfricaspa
dc.subject.keywordCentral Africaspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordVirologyspa
dc.subject.keywordAfricaeng
dc.subject.keywordAfricaeng
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHumansspa
dc.titleDistinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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