Ítem
Solo Metadatos
Sjögren's syndrome in childhood.
| dc.creator | Anaya, Juan-Manuel | |
| dc.creator | Ogawa, N. | spa |
| dc.creator | Talal N. | spa |
| dc.date.accessioned | 2020-08-28T15:48:07Z | |
| dc.date.available | 2020-08-28T15:48:07Z | |
| dc.date.created | 1995-06-01 | spa |
| dc.description.abstract | To describe the clinical characteristics of juvenile Sjögren's syndrome (JSS) and report 5 new primary cases. Patients with SS whose disease began before age 16 were identified from a cohort study on SS. Previous patients with JSS published from 1952 to 1993 were found by literature review. Thirty-nine adult patients with primary SS were selected as a control group. Five patients with primary JSS were identified and described. Thirty-four published primary JSS were reviewed. Altogether, there were 30 girls (77%). The mean age at onset was 7.8 +/- 4 years. Parotitis was the most common first symptom. An extraglandular manifestation (EGM) was the presenting feature in 9.3% of cases. Rheumatoid factor (RF) was positive in 71% and antinuclear antibodies (ANA) in 67%. During the course of disease, at least one EGM was noted in 20 cases (51%). Leukopenia was the most frequent of these (7/20, 35%). HLA-DR3 was observed in 4 of 6 cases in which HLA typing was done. Compared with adult primary SS, parotitis at onset was more frequent in children (62.5 vs 13%). The frequency of ANA and articular manifestations were higher in adults (67 vs 92%, and 15.4 vs 38.5%, respectively). We reviewed 31 cases of secondary JSS, of which the most common associated autoimmune disease was juvenile rheumatoid arthritis (42%). JSS preceded by years the associated autoimmune disease in nearly 50% of cases. JSS may be a common disease. Parotitis and the presence of RF and ANA are the main features at onset. Characteristics similar to those seen in adults are observed in children. Long-term followup is needed to assess outcome associated factors. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.issn | ISSN: 0315-162X | |
| dc.identifier.issn | EISSN: 1499-2752 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/28402 | |
| dc.language.iso | eng | spa |
| dc.publisher | The Journal of Rheumatology Publishing | spa |
| dc.relation.citationEndPage | 1158 | |
| dc.relation.citationIssue | No. 6 | |
| dc.relation.citationStartPage | 1152 | |
| dc.relation.citationTitle | Journal of Rheumatology | |
| dc.relation.citationVolume | Vol. 22 | |
| dc.relation.ispartof | Journal of Rheumatology, ISSN: 0315-162X; EISSN: 1499-2752, Vol.22, No.6 (June, 1995); pp. 1152 - 1158 | spa |
| dc.relation.uri | https://pubmed.ncbi.nlm.nih.gov/7674246/ | spa |
| dc.rights.accesRights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.acceso | Restringido (Acceso a grupos específicos) | spa |
| dc.source | Journal of Rheumatology | spa |
| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject.keyword | Sjögren's syndrome | spa |
| dc.subject.keyword | Childhood | spa |
| dc.title | Sjögren's syndrome in childhood. | spa |
| dc.title.TranslatedTitle | Síndrome de Sjögren en la infancia. | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
