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Patients with aortic stenosis referred for TAVI : Treatment decision, in-hospital outcome and determinants of survival

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dc.creatorNuis, R.J.
dc.creatorDager, A.E.
dc.creatorVan der Boon, R.M.
dc.creatorJaimes, M.C.
dc.creatorCaicedo, B.
dc.creatorFonseca, J.
dc.creatorVan Mieghem, N.M.
dc.creatorBenitez, L.M.
dc.creatorUmana, J.P.
dc.creatorO'Neill, W.W.
dc.creatorde Marchena, E.
dc.creatorde Jaegere, P.P.
dc.creator.googleNuis, R.J.spa
dc.creator.googleDager, A.E.spa
dc.creator.googleVan der Boon, R.M.spa
dc.creator.googleJaimes, M.C.spa
dc.creator.googleCaicedo, B.spa
dc.creator.googleFonseca, J.spa
dc.creator.googleVan Mieghem, N.M.spa
dc.creator.googleBenitez, L.M.spa
dc.creator.googleUmana, J.P.spa
dc.creator.googleO'Neill, W.W.spa
dc.creator.googlede Marchena, E.spa
dc.creator.googlede Jaegere, P.P.spa
dc.date.accessioned2020-05-05T23:23:16Z
dc.date.available2020-05-05T23:23:16Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractAims To assess treatment decision and outcome in patients referred for transcatheter aortic valve implantation (TAVI) in addition to predictive factors of mortality after TAVI. Methods Three-centre prospective observational study including 358 patients. Endpoints were defined according to the Valve Academic Research Consortium. Results Of the 358 patients referred for TAVI, TAVI was performed in 235 patients (65%), surgical aortic valve replacement (AVR) in 24 (7%) and medical therapy (MT) in 99 (28%). Reasons to decline TAVI in favour of AVR/MT were patient preference (29%), peripheral vascular disease (15%) and non-severe aortic stenosis (11%). The logistic EuroSCORE was significantly higher in patients who underwent TAVI and MT in comparison with those undergoing AVR (19 vs. 10%, p=0.007). At 30 days, all-cause mortality and the combined safety endpoint were 9 and 24% after TAVI and 8 and 25% after AVR, respectively. All-cause mortality was significantly lower in the TAVI group compared with the MT group at 6 months, 1 year and 2 years (12% vs. 22%, 21% vs. 33% and 31% vs. 55%, respectively, p<0.001). Multivariable analysis revealed that blood transfusion (HR: 1.19; 95% CI: 1.05-1.33), pre-existing renal failure (HR: 1.18; 95% CI: 1.06-1.33) and STS score (HR: 1.06; 95% CI: 1.02-1.10) were independent predictors of mortality at a median of 10 (IQR: 3-23) months after TAVI. Conclusions Approximately two-thirds of the patients referred for TAVI receive this treatment with gratifying short- and long-term survival. Another 7% underwent AVR. Prognosis is poor in patients who do not receive valve replacement therapy. © The Author(s) 2011.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12471-011-0224-z
dc.identifier.issn1568-5888
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21871
dc.language.isoengspa
dc.relation.citationEndPage23
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage16
dc.relation.citationTitleNetherlands Heart Journal
dc.relation.citationVolumeVol. 20
dc.relation.ispartofNetherlands Heart Journal, ISSN: 1568-5888 Vol. 20, No. 1 (2012) pp. 16-23spa
dc.relation.urihttps://link.springer.com/content/pdf/10.1007%2Fs12471-011-0224-z.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcPromoción de saludspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAortic stenosisspa
dc.subject.keywordTranscatheter aortic valve implantationspa
dc.subject.keywordSurgical aortic valve replacementspa
dc.subject.keywordTreatment decisionspa
dc.subject.keywordComplicationsspa
dc.subject.keywordPrognosisspa
dc.titlePatients with aortic stenosis referred for TAVI : Treatment decision, in-hospital outcome and determinants of survivalspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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