Ítem
Acceso Abierto

The fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centers

Mostrar el registro sencillo de la publicación
dc.creatorNacher, Mathieuspa
dc.creatorLeitao, Terezinha Silvaspa
dc.creatorGómez, Beatriz L.spa
dc.creatorCouppié, Pierrespa
dc.creatorAdenis, Antoinespa
dc.creatorDamasceno, Lisandraspa
dc.creatorDemar, Magaliespa
dc.creatorSamayoa, Blancaspa
dc.creatorCáceres, Diego H.spa
dc.creatorPradinaud, Rogerspa
dc.creatorde Queiroz Sousa, Anastaciospa
dc.creatorArathoon, Eduardospa
dc.creatorRestrepo, Angelaspa
dc.date.accessioned2020-05-25T23:56:10Z
dc.date.available2020-05-25T23:56:10Z
dc.date.created2019spa
dc.description.abstractDisseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas inMedellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. © 2019 by the authors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/jof5020051
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22349
dc.language.isoengspa
dc.publisherMDPI AGspa
dc.relation.citationIssueNo. 2
dc.relation.citationTitleJournal of Fungi
dc.relation.citationVolumeVol. 5
dc.relation.ispartofJournal of Fungi, Vol.5, No.2 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071665096&doi=10.3390%2fjof5020051&partnerID=40&md5=877a0682311d26302629cbf26b389f7fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAwarenessspa
dc.subject.keywordHistoplasmosisspa
dc.subject.keywordHivspa
dc.subject.keywordLatin americaspa
dc.subject.keywordLeishmaniasisspa
dc.titleThe fight against HIV-associated disseminated histoplasmosis in the Americas: Unfolding the different stories of four centersspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
jof-05-00051.pdf
Tamaño:
661.58 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos