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Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis

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dc.creatorDiaz F.J.spa
dc.creatorRojas-Villarraga A.spa
dc.creatorSalazar J.C.spa
dc.creatorIglesias-Gamarra A.spa
dc.creatorMantilla R.D.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:46Z
dc.date.available2020-05-25T23:55:46Z
dc.date.created2011spa
dc.description.abstractObjectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA. © 2010 Société française de rhumatologie.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jbspin.2010.07.014
dc.identifier.issn1297319X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22210
dc.language.isoengspa
dc.relation.citationEndPage178
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage175
dc.relation.citationTitleJoint Bone Spine
dc.relation.citationVolumeVol. 78
dc.relation.ispartofJoint Bone Spine, ISSN:1297319X, Vol.78, No.2 (2011); pp. 175-178spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79952250830&doi=10.1016%2fj.jbspin.2010.07.014&partnerID=40&md5=bcdc9eb7e8ff2fc45bd3b3bf855bd9bespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCyclic citrullinated peptide antibodyspa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordrheumatoideng
dc.subject.keywordcycliceng
dc.subject.keywordanti-idiotypiceng
dc.subject.keywordArticlespa
dc.subject.keywordDisease associationspa
dc.subject.keywordFemalespa
dc.subject.keywordGene sequencespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordOnset agespa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRisk factorspa
dc.subject.keywordAdultspa
dc.subject.keywordAge of onsetspa
dc.subject.keywordAntibodieseng
dc.subject.keywordArthritiseng
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPeptideseng
dc.subject.keywordPolymorphismeng
dc.subject.keywordRegression analysisspa
dc.subject.keywordRetrospective studiesspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordAgespa
dc.subject.keywordAnti-ccp antibodiesspa
dc.subject.keywordHla-drb1spa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordSmokingspa
dc.subject.keywordTnf-308 a allelespa
dc.titleAnti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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